Prespecified levels for dose escalation of CLAG-M and venetoclax
| Level . | Cladribine . | Cytarabine . | Mitoxantrone . | Venetoclax . |
|---|---|---|---|---|
| 1 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 10 mg/m2 days 1-3 | 200 mg daily days 1-14 |
| 2 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 10 mg/m2 days 1-3 | 400 mg daily days 1-14 |
| 3 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 16 or 18 mg/m2 days 1-3∗ | 400 mg daily days 1-14 |
| 4 | 5 mg/m2 days 1-5 | 2 g/m2 days 1-5 | 16 or 18 mg/m2 days 1-3∗ | 400 mg daily days 1-14 |
| Level . | Cladribine . | Cytarabine . | Mitoxantrone . | Venetoclax . |
|---|---|---|---|---|
| 1 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 10 mg/m2 days 1-3 | 200 mg daily days 1-14 |
| 2 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 10 mg/m2 days 1-3 | 400 mg daily days 1-14 |
| 3 | 5 mg/m2 days 1-5 | 1.5 g/m2 days 1-5 | 16 or 18 mg/m2 days 1-3∗ | 400 mg daily days 1-14 |
| 4 | 5 mg/m2 days 1-5 | 2 g/m2 days 1-5 | 16 or 18 mg/m2 days 1-3∗ | 400 mg daily days 1-14 |
Patients with new diagnosis received a dose of 18 mg/m2 and patients with R/R disease received a dose of 16 mg/m2.