PK parameters of RO7283420 following a single IV dose in group I patients
| Parameter . | Dose (mg) . | ||||
|---|---|---|---|---|---|
| 0.15∗ . | 0.5∗ . | 1.0 . | 2.0 . | 4.0 . | |
| Tmax, n | 1 | 1 | 39 | 3 | 5 |
| Median, h∗ | 5.93 | 4.08 | 4.17 | 4.37 | 4.17 |
| Range, min-max, h | n/a | n/a | 0.50-7 | 4.13-4.75 | 3.50-6.08 |
| Cmax, n | 1 | 1 | 39 | 3 | 5 |
| Geo mean, μg/mL∗ | 0.0388 | 0.100 | 0.274 | 0.560 | 0.944 |
| Geo CV%, μg/mL | n/a | n/a | 50.14 | 20.31 | 27.85 |
| Cmax_D, n | 1 | 1 | 39 | 3 | 5 |
| Geo mean, ug/mL/mg∗ | 0.259 | 0.200 | 0.287 | 0.28 | 0.244 |
| Geo CV%, ug/mL/mg | n/a | n/a | 45.58 | 20.31 | 24.56 |
| AUC0-24, n | 1 | 1 | 38 | 3 | 5 |
| Geo mean, h∗ug/mL∗ | 0.681 | 1.78 | 3.98 | 7.75 | 14.2 |
| Geo CV%, h∗ug/mL | n/a | n/a | 54.54 | 16.22 | 39.28 |
| AUC0-168, n | 1 | 1 | 26 | 3 | 5 |
| Geo mean, h∗ug/mL∗ | 2.16 | 6.50 | 10.2 | 23.2 | 44.2 |
| Geo CV%, h∗ug/mL | n/a | n/a | 62.74 | 53.55 | 51.1 |
| DnormAUC168h, n | 1 | 1 | 26 | 3 | 5 |
| Geo mean, (h∗ug/mL)/mg∗ | 14.4 | 13.0 | 10.2 | 11.6 | 11.4 |
| Geo CV%, (h∗ug/mL)/mg | n/a | n/a | 62.61 | 53.55 | 47.47 |
| Terminal half-life, n | 1 | 1 | 25 | 3 | 5 |
| Median, h∗ | 61.5 | 84.1 | 29.09 | 76.41 | 80.67 |
| Range (min-max), h | n/a | n/a | 7.46-74.6 | 26.5-119 | 34.2-90.2 |
| Vss_obs, n | 1 | 1 | 25 | 3 | 5 |
| Geo mean, L∗ | 4.99 | 6.79 | 3.81 | 5.72 | 6.27 |
| Geo CV%, L | n/a | n/a | 35 | 7.6 | 21 |
| Cl_obs, n | 1 | 1 | 25 | 3 | 5 |
| Geo mean, mL/h∗ | 59.0 | 58.1 | 90.7 | 69.4 | 72.9 |
| Geo CV%, mL/h | n/a | n/a | 63.79 | 80 | 59.87 |
| Parameter . | Dose (mg) . | ||||
|---|---|---|---|---|---|
| 0.15∗ . | 0.5∗ . | 1.0 . | 2.0 . | 4.0 . | |
| Tmax, n | 1 | 1 | 39 | 3 | 5 |
| Median, h∗ | 5.93 | 4.08 | 4.17 | 4.37 | 4.17 |
| Range, min-max, h | n/a | n/a | 0.50-7 | 4.13-4.75 | 3.50-6.08 |
| Cmax, n | 1 | 1 | 39 | 3 | 5 |
| Geo mean, μg/mL∗ | 0.0388 | 0.100 | 0.274 | 0.560 | 0.944 |
| Geo CV%, μg/mL | n/a | n/a | 50.14 | 20.31 | 27.85 |
| Cmax_D, n | 1 | 1 | 39 | 3 | 5 |
| Geo mean, ug/mL/mg∗ | 0.259 | 0.200 | 0.287 | 0.28 | 0.244 |
| Geo CV%, ug/mL/mg | n/a | n/a | 45.58 | 20.31 | 24.56 |
| AUC0-24, n | 1 | 1 | 38 | 3 | 5 |
| Geo mean, h∗ug/mL∗ | 0.681 | 1.78 | 3.98 | 7.75 | 14.2 |
| Geo CV%, h∗ug/mL | n/a | n/a | 54.54 | 16.22 | 39.28 |
| AUC0-168, n | 1 | 1 | 26 | 3 | 5 |
| Geo mean, h∗ug/mL∗ | 2.16 | 6.50 | 10.2 | 23.2 | 44.2 |
| Geo CV%, h∗ug/mL | n/a | n/a | 62.74 | 53.55 | 51.1 |
| DnormAUC168h, n | 1 | 1 | 26 | 3 | 5 |
| Geo mean, (h∗ug/mL)/mg∗ | 14.4 | 13.0 | 10.2 | 11.6 | 11.4 |
| Geo CV%, (h∗ug/mL)/mg | n/a | n/a | 62.61 | 53.55 | 47.47 |
| Terminal half-life, n | 1 | 1 | 25 | 3 | 5 |
| Median, h∗ | 61.5 | 84.1 | 29.09 | 76.41 | 80.67 |
| Range (min-max), h | n/a | n/a | 7.46-74.6 | 26.5-119 | 34.2-90.2 |
| Vss_obs, n | 1 | 1 | 25 | 3 | 5 |
| Geo mean, L∗ | 4.99 | 6.79 | 3.81 | 5.72 | 6.27 |
| Geo CV%, L | n/a | n/a | 35 | 7.6 | 21 |
| Cl_obs, n | 1 | 1 | 25 | 3 | 5 |
| Geo mean, mL/h∗ | 59.0 | 58.1 | 90.7 | 69.4 | 72.9 |
| Geo CV%, mL/h | n/a | n/a | 63.79 | 80 | 59.87 |
AUC, area under the curve; CI, clearance; DnormAUC168h, dose-normalized area under the curve from 0 h to 168 h post most recent dose; Geo CV, geometric coefficient of variation; Geo mean, geometric mean; h, hours; IV, intravenous; max, maximum; min, minimum; n/a, not applicable; obs, observed; PK, pharmacokinetic; Vss, volume of distribution at steady state.
In case of n = 1 in a cohort, the individual values for the single participant are given.