Rates of CAR T-cell–related toxicities, CRS, and ICANS in patients with R/R CNS B-ALL compared with patients with R/R B-ALL without CNS involvement
Toxicity/Grade . | Patients with CNS disease (n = 31) . | Non-CNS ROCCA population (n = 158) . | P value . |
---|---|---|---|
CRS, n (%) | |||
Grade 3/4 | 1 (3.2) | 19 (12.0) | .2065 |
All grades | 23 (74.2) | 134 (84.8) | .1049 |
ICANS, n (%) | |||
Grade 3/4 | 11 (35.5) | 48 (30.4) | .575 |
All grades | 20 (64.5) | 86 (54.4) | .3177 |
Toxicity/Grade . | Patients with CNS disease (n = 31) . | Non-CNS ROCCA population (n = 158) . | P value . |
---|---|---|---|
CRS, n (%) | |||
Grade 3/4 | 1 (3.2) | 19 (12.0) | .2065 |
All grades | 23 (74.2) | 134 (84.8) | .1049 |
ICANS, n (%) | |||
Grade 3/4 | 11 (35.5) | 48 (30.4) | .575 |
All grades | 20 (64.5) | 86 (54.4) | .3177 |