Table 2.

Rates of CAR T-cell–related toxicities, CRS, and ICANS in patients with R/R CNS B-ALL compared with patients with R/R B-ALL without CNS involvement

Toxicity/GradePatients with CNS disease (n = 31)Non-CNS ROCCA population (n = 158)P value
CRS, n (%)    
Grade 3/4 1 (3.2) 19 (12.0) .2065 
All grades 23 (74.2) 134 (84.8) .1049 
ICANS, n (%)    
Grade 3/4 11 (35.5) 48 (30.4) .575 
All grades 20 (64.5) 86 (54.4) .3177 
Toxicity/GradePatients with CNS disease (n = 31)Non-CNS ROCCA population (n = 158)P value
CRS, n (%)    
Grade 3/4 1 (3.2) 19 (12.0) .2065 
All grades 23 (74.2) 134 (84.8) .1049 
ICANS, n (%)    
Grade 3/4 11 (35.5) 48 (30.4) .575 
All grades 20 (64.5) 86 (54.4) .3177 

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