Patients with clonal evolution or PNH during follow-up
| ID . | Age at diagnosis, y . | Age at clonal evolution/PNH, y . | Cellularity at diagnosis/during the course . | Diagnosis . | Karyotype . | Clinical course/outcome at last FU (age in years) . |
|---|---|---|---|---|---|---|
| D1128 | 13 | 16 | Hypocellular/hypocellular | RCC | 46,XY,+der(1)t(1;13) (p12;q13),-13[3]/46,XY[17] FISH negative for monosomy 7 | No therapy, normal karyotype again in subsequent examinations, alive (21) |
| D1254 | 13 | 17 | Hypocellular/hypocellular | RCC | 45,XY,-7,inc [3] FISH negative for monosomy 7 | No therapy, normal karyotype again in subsequent examinations, alive (19) |
| D682 | 9 | 18 | Hypocellular/no data | MDS-EB | Partial trisomy 21q22 | HSCT, alive in remission (13) |
| D309 | 17 | 19 | Hypocellular/no data | PNH (hemolysis) | — | HSCT, graft failure, second HSCT, alive (31) |
| D656 | 7 | 17 | Hypocellular/hypocellular | PNH (hemolysis/thrombosis) | — | Eculizumab, alive (18) |
| D806 | 7 | 8 | Hypercellular/no data | PNH (hemolysis) | — | HSCT, alive (19) |
| ID . | Age at diagnosis, y . | Age at clonal evolution/PNH, y . | Cellularity at diagnosis/during the course . | Diagnosis . | Karyotype . | Clinical course/outcome at last FU (age in years) . |
|---|---|---|---|---|---|---|
| D1128 | 13 | 16 | Hypocellular/hypocellular | RCC | 46,XY,+der(1)t(1;13) (p12;q13),-13[3]/46,XY[17] FISH negative for monosomy 7 | No therapy, normal karyotype again in subsequent examinations, alive (21) |
| D1254 | 13 | 17 | Hypocellular/hypocellular | RCC | 45,XY,-7,inc [3] FISH negative for monosomy 7 | No therapy, normal karyotype again in subsequent examinations, alive (19) |
| D682 | 9 | 18 | Hypocellular/no data | MDS-EB | Partial trisomy 21q22 | HSCT, alive in remission (13) |
| D309 | 17 | 19 | Hypocellular/no data | PNH (hemolysis) | — | HSCT, graft failure, second HSCT, alive (31) |
| D656 | 7 | 17 | Hypocellular/hypocellular | PNH (hemolysis/thrombosis) | — | Eculizumab, alive (18) |
| D806 | 7 | 8 | Hypercellular/no data | PNH (hemolysis) | — | HSCT, alive (19) |
PNH clone at diagnosis: D309, not examined; D656, granulocyte 1%, monocyte 3%, erythrocyte 1%; D806, granulocyte 6%, monocyte 25%, erythrocyte 2%.
FU, follow-up; MDS-EB, myelodysplastic syndrome with excess blasts.