Associations between change in symptoms/unmet needs over 12 months and HrQOL as measured by change in FACT-G over 12 months
| Change variable (12-month enrollment) . | n . | Change estimate∗ . | 95% CI . | P value . |
|---|---|---|---|---|
| BPI total | 119 | −1.42 | −2.14 to −0.70 | .0002 |
| Change to clinically relevant pain | 126 | −6.70 | −12.80 to −0.61 | .03 |
| BFI total | 118 | −1.69 | −2.36 to −1.02 | <.0001 |
| Change to clinically relevant fatigue | 126 | −5.55 | −12.13 to 1.03 | .10 |
| Top 3 ECD-SS symptoms: severity | 118 | −1.92 | −2.82 to −1.03 | <.0001 |
| Top 5 ECD-SS symptoms: severity | 118 | −1.84 | −2.75 to −0.94 | .0001 |
| Sustained unmet health care service needs | 126 | 2.35 | −2.87 to 7.57 | .37 |
| Sustained unmet psychological/emotional needs | 126 | 2.66 | −1.46 to 6.77 | .20 |
| Sustained unmet physical and daily health needs | 126 | 1.34 | −2.64 to 5.33 | .51 |
| Sustained unmet care and support needs | 126 | 2.46 | −4.75 to 9.67 | .50 |
| Sustained unmet sexual needs | 126 | 3.95 | −2.43 to 10.33 | .22 |
| Change to met health care service needs | 126 | 5.31 | 0.16-10.47 | .04 |
| Change to met psychological/emotional needs | 126 | 5.76 | 0.81-10.71 | .02 |
| Change to met physical and daily health needs | 126 | 7.20 | 1.90-12.50 | .008 |
| Change to met care and support needs | 126 | 6.32 | 1.10-11.55 | .02 |
| Change to met sexual needs | 126 | −0.33 | −6.19 to 5.54 | .91 |
| Increasing no. of unmet needs | 125 | −0.79 | −1.07 to −0.51 | <.0001 |
| Change variable (12-month enrollment) . | n . | Change estimate∗ . | 95% CI . | P value . |
|---|---|---|---|---|
| BPI total | 119 | −1.42 | −2.14 to −0.70 | .0002 |
| Change to clinically relevant pain | 126 | −6.70 | −12.80 to −0.61 | .03 |
| BFI total | 118 | −1.69 | −2.36 to −1.02 | <.0001 |
| Change to clinically relevant fatigue | 126 | −5.55 | −12.13 to 1.03 | .10 |
| Top 3 ECD-SS symptoms: severity | 118 | −1.92 | −2.82 to −1.03 | <.0001 |
| Top 5 ECD-SS symptoms: severity | 118 | −1.84 | −2.75 to −0.94 | .0001 |
| Sustained unmet health care service needs | 126 | 2.35 | −2.87 to 7.57 | .37 |
| Sustained unmet psychological/emotional needs | 126 | 2.66 | −1.46 to 6.77 | .20 |
| Sustained unmet physical and daily health needs | 126 | 1.34 | −2.64 to 5.33 | .51 |
| Sustained unmet care and support needs | 126 | 2.46 | −4.75 to 9.67 | .50 |
| Sustained unmet sexual needs | 126 | 3.95 | −2.43 to 10.33 | .22 |
| Change to met health care service needs | 126 | 5.31 | 0.16-10.47 | .04 |
| Change to met psychological/emotional needs | 126 | 5.76 | 0.81-10.71 | .02 |
| Change to met physical and daily health needs | 126 | 7.20 | 1.90-12.50 | .008 |
| Change to met care and support needs | 126 | 6.32 | 1.10-11.55 | .02 |
| Change to met sexual needs | 126 | −0.33 | −6.19 to 5.54 | .91 |
| Increasing no. of unmet needs | 125 | −0.79 | −1.07 to −0.51 | <.0001 |
Change estimate interpretation: a 1-unit increase in the change in symptom variable over time (12-months minus enrollment) is associated with this change estimate in HrQOL on average as measured by total FACT-G score over time (12-months minus enrollment). For example, a patient who has a total BPI score increase from 5 points at enrollment to 6 points at 12-months will have, on average, a decreased total FACT-G score of 1.42 points (correlating with decreased HrQOL) over the same time period. Another example: a patient who has unmet health care service needs at enrollment but met health care service needs at 12 months will have, on average, an increased total FACT-G score of 5.31 points (correlating with increased HrQOL) over the same time period.