Examples of HLA matching with recipients in DUCBT between WUs and LUs
| Example . | Identity . | HLA-A . | HLA-B . | HLA-C . | HLA-DRB1 . | Explanation . | Interpretation Nonengrafting unit is matched with recipient for whom the WU is mismatched (true/false) . |
|---|---|---|---|---|---|---|---|
| 1 | Recipient 1 | ∗01,32 | ∗08, ∗44 | ∗07, ∗12 | ∗04:07, 16∗01 | Recipient and LU are matched for HLA-B∗44, but WU is mismatched and carries B∗39 | True |
| LU 1 | ∗01,32 | ∗08, ∗44 | ∗07, ∗12 | ∗04:07, 16∗01 | |||
| WU 1 | ∗01,32 | ∗08, ∗39 | ∗07, ∗12 | ∗04:07, 16∗01 | |||
| 2 | Recipient 2 | ∗11, ∗25 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | Recipient and LU are mismatched for HLA-A∗25 (LU carried HLA-A∗03) but WU is matched | False |
| LU 2 | ∗11, ∗03 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | |||
| WU 2 | ∗11, ∗25 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | |||
| 3 | Recipient 3 | ∗02, ∗68 | ∗49, ∗51 | ∗07, ∗16 | ∗07:01, ∗14:04 | Both donors have identical mismatches. | False |
| LU 3 | ∗02, ∗30 | ∗49, ∗51 | ∗02, ∗16 | ∗09:01, ∗14:04 | |||
| WU 3 | ∗02, ∗30 | ∗49, ∗51 | ∗02, ∗16 | ∗09:01, ∗14:04 | |||
| 4 | Recipient 4 | ∗68, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:01, ∗15:03 | Recipient and LU are mismatched for HLA-DRB1∗15:05 (vs∗04:07) but matched for A∗68 and DRB1∗11:01 with WU mismatched. | True |
| LU 4 | ∗68, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:01, ∗04:07 | |||
| WU 4 | ∗01, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:02, ∗15:03 |
| Example . | Identity . | HLA-A . | HLA-B . | HLA-C . | HLA-DRB1 . | Explanation . | Interpretation Nonengrafting unit is matched with recipient for whom the WU is mismatched (true/false) . |
|---|---|---|---|---|---|---|---|
| 1 | Recipient 1 | ∗01,32 | ∗08, ∗44 | ∗07, ∗12 | ∗04:07, 16∗01 | Recipient and LU are matched for HLA-B∗44, but WU is mismatched and carries B∗39 | True |
| LU 1 | ∗01,32 | ∗08, ∗44 | ∗07, ∗12 | ∗04:07, 16∗01 | |||
| WU 1 | ∗01,32 | ∗08, ∗39 | ∗07, ∗12 | ∗04:07, 16∗01 | |||
| 2 | Recipient 2 | ∗11, ∗25 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | Recipient and LU are mismatched for HLA-A∗25 (LU carried HLA-A∗03) but WU is matched | False |
| LU 2 | ∗11, ∗03 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | |||
| WU 2 | ∗11, ∗25 | ∗51, ∗58 | ∗07, ∗15 | ∗04:03, ∗13:01 | |||
| 3 | Recipient 3 | ∗02, ∗68 | ∗49, ∗51 | ∗07, ∗16 | ∗07:01, ∗14:04 | Both donors have identical mismatches. | False |
| LU 3 | ∗02, ∗30 | ∗49, ∗51 | ∗02, ∗16 | ∗09:01, ∗14:04 | |||
| WU 3 | ∗02, ∗30 | ∗49, ∗51 | ∗02, ∗16 | ∗09:01, ∗14:04 | |||
| 4 | Recipient 4 | ∗68, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:01, ∗15:03 | Recipient and LU are mismatched for HLA-DRB1∗15:05 (vs∗04:07) but matched for A∗68 and DRB1∗11:01 with WU mismatched. | True |
| LU 4 | ∗68, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:01, ∗04:07 | |||
| WU 4 | ∗01, ∗74 | ∗35, ∗53 | ∗04, - | ∗11:02, ∗15:03 |
HLA typing is considered at low resolution for HLA-A, -B, and-C, and at high resolution for HLA-DRB1. HLA mismatching with the recipient is highlighted in bold font for both WU and LU. Homozygosity is indicated by a hyphen (-).