Clonality of LPDs
| Genotype . | ID . | Clone . | VH . | D . | JH . | Mutation . | HCDR3 . |
|---|---|---|---|---|---|---|---|
| Ezh2 KO | 1092-17 | Mono | V6-3 | D3-1 | JH3 | (U) | T G G G S W F A Y |
| Ezh2 KO | 1092-24 | Mono | V1-52 | D2-8 | JH4 | (M) | T R G G Y S G H Y G A V D Y |
| Ezh2 KO | 1092-20 | Mono | V12-3 | D4-1 | JH1 | (U) | A G D R T G Y W Y F D V |
| A/E dKO | 1093-7 | Mono | V12-3 | D1-1 | JH1 | (U) | A R D S Y G Y W Y F D V |
| A/E dKO | 1078-26 | Mono | V12-3 | D4-1 | JH1 | (U) | A G D I G G Y W Y F D V |
| A/E dKO | 1092-26 | Mono | V1-58 | D2-5 | JH4 | (U) | A R S D Y S N Y V S Y Y Y A M D Y |
| Genotype . | ID . | Clone . | VH . | D . | JH . | Mutation . | HCDR3 . |
|---|---|---|---|---|---|---|---|
| Ezh2 KO | 1092-17 | Mono | V6-3 | D3-1 | JH3 | (U) | T G G G S W F A Y |
| Ezh2 KO | 1092-24 | Mono | V1-52 | D2-8 | JH4 | (M) | T R G G Y S G H Y G A V D Y |
| Ezh2 KO | 1092-20 | Mono | V12-3 | D4-1 | JH1 | (U) | A G D R T G Y W Y F D V |
| A/E dKO | 1093-7 | Mono | V12-3 | D1-1 | JH1 | (U) | A R D S Y G Y W Y F D V |
| A/E dKO | 1078-26 | Mono | V12-3 | D4-1 | JH1 | (U) | A G D I G G Y W Y F D V |
| A/E dKO | 1092-26 | Mono | V1-58 | D2-5 | JH4 | (U) | A R S D Y S N Y V S Y Y Y A M D Y |
Analysis of IGHVDJ from splenocytes of MDS/MPN LPD mice.
A/E dKO, Asxl1/Ezh2 dKO; D, diversity region; HCDR3, heavy chain complementary determining region; ID, identifier; JH, joining region heavy chain; M, mutated IGHV; Mono, monoclone; U, unmuted IGHV; VH, variable domain heavy chain.