Characteristics of 6043 patients with MPN, 2012-2019
| Baseline characteristics . | Overall . | RUX . | P value . | |
|---|---|---|---|---|
| n (%) . | Yes . | No . | ||
| n (%) . | n (%) . | |||
| Total | 6043 | 513 | 5530 | |
| Previous HU | ||||
| No | 1865 (30.9) | 268 (52.2) | 1597 (28.9) | <.01 |
| Yes | 4178 (69.1) | 245 (47.8) | 3933 (71.1) | |
| Type of MPN | ||||
| PV | 2396 (39.6) | 153 (29.8) | 2243 (40.6) | <.01 |
| ET | 2944 (48.7) | 76 (14.8) | 2868 (51.9) | |
| MF | 703 (11.6) | 284 (55.4) | 419 (7.6) | |
| Age, y | ||||
| Median (IQR) | 76 (71-82) | 75 (70-80) | 76 (71-83) | |
| 66-69 | 1075 (17.8) | 106 (20.7) | 969 (17.5) | <.01 |
| 70-74 | 1459 (24.1) | 146 (28.5) | 1313 (23.7) | |
| 75-79 | 1330 (22.0) | 128 (25.0) | 1202 (21.7) | |
| 80-84 | 1110 (18.4) | 87 (17.0) | 1023 (18.5) | |
| ≥85 | 1069 (17.7) | 46 (9.0) | 1023 (18.5) | |
| Sex | ||||
| Female | 3597 (59.5) | 261 (50.9) | 3336 (60.3) | <.01 |
| Male | 2446 (40.5) | 252 (49.1) | 2194 (39.7) | |
| Race | ||||
| White | 5200 (86.0) | 452 (88.1) | 4748 (85.9) | .16 |
| Other | 843 (14.0) | 61 (11.9) | 782 (14.1) | |
| Marital status | ||||
| Single | 1940 (32.1) | 184 (35.9) | 1756 (31.8) | .03 |
| Married | 3652 (60.4) | 285 (55.6) | 3367 (60.9) | |
| Unknown | 451 (7.5) | 44 (8.6) | 407 (7.4) | |
| Region | ||||
| Northeast | 2611 (43.2) | 215 (41.9) | 2396 (43.3) | <.01 |
| Midwest | 440 (7.3) | 35 (6.8) | 405 (7.3) | |
| South | 1434 (23.7) | 95 (18.5) | 1339 (24.2) | |
| West | 1558 (25.8) | 168 (32.7) | 1390 (25.1) | |
| Elixhauser comorbidity Index | ||||
| 0 | 2129 (35.2) | 209 (40.7) | 1920 (34.7) | <.01 |
| 1-2 | 2385 (39.5) | 172 (33.5) | 2213 (40.0) | |
| ≥3 | 1529 (25.3) | 132 (25.7) | 1397 (25.3) | |
| Previous cancer | ||||
| No | 4612 (76.3) | 368 (71.7) | 4244 (76.7) | .01 |
| Yes | 1431 (23.7) | 145 (28.3) | 1286 (23.3) | |
| Frail | ||||
| No | 4440 (73.5) | 400 (78.0) | 4040 (73.1) | .02 |
| Yes | 1603 (26.5) | 113 (22.0) | 1490 (26.9) | |
| Yost index | ||||
| Fifth quintile (highest SES) | 2063 (34.1) | 181 (35.3) | 1882 (34.0) | .35 |
| Fourth quintile | 1309 (21.7) | 119 (23.2) | 1190 (21.5) | |
| Third quintile | 952 (15.8) | 84 (16.4) | 868 (15.7) | |
| Second quintile | 867 (14.3) | 62 (12.1) | 805 (14.6) | |
| First quintile (lowest SES) | 643 (10.6) | 46 (9.0) | 597 (10.8) | |
| Unknown | 209 (3.5) | 21 (4.1) | 188 (3.4) | |
| State buy-in | ||||
| No | 5197 (86.0) | 446 (86.9) | 4751 (85.9) | .52 |
| Yes | 846 (14.0) | 67 (13.1) | 779 (14.1) | .00 |
| Nonmetropolitan area | ||||
| No | 5087 (84.2) | 456 (88.9) | 4631 (83.7) | <.01 |
| Yes | >945 (>15.6) | 57 (11.1) | >888 (>16.1) | |
| Unknown | <11 (<0.2) | <11 (<0.2) | ||
| Baseline characteristics . | Overall . | RUX . | P value . | |
|---|---|---|---|---|
| n (%) . | Yes . | No . | ||
| n (%) . | n (%) . | |||
| Total | 6043 | 513 | 5530 | |
| Previous HU | ||||
| No | 1865 (30.9) | 268 (52.2) | 1597 (28.9) | <.01 |
| Yes | 4178 (69.1) | 245 (47.8) | 3933 (71.1) | |
| Type of MPN | ||||
| PV | 2396 (39.6) | 153 (29.8) | 2243 (40.6) | <.01 |
| ET | 2944 (48.7) | 76 (14.8) | 2868 (51.9) | |
| MF | 703 (11.6) | 284 (55.4) | 419 (7.6) | |
| Age, y | ||||
| Median (IQR) | 76 (71-82) | 75 (70-80) | 76 (71-83) | |
| 66-69 | 1075 (17.8) | 106 (20.7) | 969 (17.5) | <.01 |
| 70-74 | 1459 (24.1) | 146 (28.5) | 1313 (23.7) | |
| 75-79 | 1330 (22.0) | 128 (25.0) | 1202 (21.7) | |
| 80-84 | 1110 (18.4) | 87 (17.0) | 1023 (18.5) | |
| ≥85 | 1069 (17.7) | 46 (9.0) | 1023 (18.5) | |
| Sex | ||||
| Female | 3597 (59.5) | 261 (50.9) | 3336 (60.3) | <.01 |
| Male | 2446 (40.5) | 252 (49.1) | 2194 (39.7) | |
| Race | ||||
| White | 5200 (86.0) | 452 (88.1) | 4748 (85.9) | .16 |
| Other | 843 (14.0) | 61 (11.9) | 782 (14.1) | |
| Marital status | ||||
| Single | 1940 (32.1) | 184 (35.9) | 1756 (31.8) | .03 |
| Married | 3652 (60.4) | 285 (55.6) | 3367 (60.9) | |
| Unknown | 451 (7.5) | 44 (8.6) | 407 (7.4) | |
| Region | ||||
| Northeast | 2611 (43.2) | 215 (41.9) | 2396 (43.3) | <.01 |
| Midwest | 440 (7.3) | 35 (6.8) | 405 (7.3) | |
| South | 1434 (23.7) | 95 (18.5) | 1339 (24.2) | |
| West | 1558 (25.8) | 168 (32.7) | 1390 (25.1) | |
| Elixhauser comorbidity Index | ||||
| 0 | 2129 (35.2) | 209 (40.7) | 1920 (34.7) | <.01 |
| 1-2 | 2385 (39.5) | 172 (33.5) | 2213 (40.0) | |
| ≥3 | 1529 (25.3) | 132 (25.7) | 1397 (25.3) | |
| Previous cancer | ||||
| No | 4612 (76.3) | 368 (71.7) | 4244 (76.7) | .01 |
| Yes | 1431 (23.7) | 145 (28.3) | 1286 (23.3) | |
| Frail | ||||
| No | 4440 (73.5) | 400 (78.0) | 4040 (73.1) | .02 |
| Yes | 1603 (26.5) | 113 (22.0) | 1490 (26.9) | |
| Yost index | ||||
| Fifth quintile (highest SES) | 2063 (34.1) | 181 (35.3) | 1882 (34.0) | .35 |
| Fourth quintile | 1309 (21.7) | 119 (23.2) | 1190 (21.5) | |
| Third quintile | 952 (15.8) | 84 (16.4) | 868 (15.7) | |
| Second quintile | 867 (14.3) | 62 (12.1) | 805 (14.6) | |
| First quintile (lowest SES) | 643 (10.6) | 46 (9.0) | 597 (10.8) | |
| Unknown | 209 (3.5) | 21 (4.1) | 188 (3.4) | |
| State buy-in | ||||
| No | 5197 (86.0) | 446 (86.9) | 4751 (85.9) | .52 |
| Yes | 846 (14.0) | 67 (13.1) | 779 (14.1) | .00 |
| Nonmetropolitan area | ||||
| No | 5087 (84.2) | 456 (88.9) | 4631 (83.7) | <.01 |
| Yes | >945 (>15.6) | 57 (11.1) | >888 (>16.1) | |
| Unknown | <11 (<0.2) | <11 (<0.2) | ||
SES, socioeconomic status.