HRs and 95% CIs from multivariable competing risk regression models for SMs among 6043 patients with MPN
| . | Model 1, RUX (yes/no) . | Model 2, RUX PDC . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| RUX | ||||
| No | 1.00 | |||
| Yes | 0.96 (0.65-1.42) | .84 | ||
| PDC (per 10%) | 1.00 (0.96-1.05) | .95 | ||
| Previous HU | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.01 (0.83-1.24) | .91 | 1.01 (0.83-1.24) | .90 |
| Type of MPN | ||||
| PV | 1.00 | 1.00 | ||
| ET | 0.95 (0.78-1.16) | .60 | 0.95 (0.78-1.16) | .62 |
| MF | 0.91 (0.64-1.27) | .57 | 0.89 (0.63-1.25) | .50 |
| Age, y | ||||
| 66-69 | 1.00 | 1.00 | ||
| 70-74 | 0.99 (0.75-1.31) | .94 | 0.99 (0.75-1.31) | .94 |
| 75-79 | 1.10 (0.83-1.46) | .49 | 1.10 (0.83-1.46) | .49 |
| 80-84 | 0.83 (0.61-1.13) | .23 | 0.83 (0.61-1.13) | .23 |
| ≥85 | 0.62 (0.44-0.88) | <.01 | 0.62 (0.44-0.89) | <.01 |
| Sex | ||||
| Female | 1.00 | 1.00 | ||
| Male | 1.38 (1.14-1.67) | <.01 | 1.38 (1.14-1.67) | <.01 |
| Race | ||||
| White | 1.00 | 1.00 | ||
| Other | 0.80 (0.60-1.09) | .16 | 0.81 (0.60-1.09) | .16 |
| Marital status | ||||
| Married | 1.00 | 1.00 | ||
| Unmarried | 1.06 (0.86-1.31) | .60 | 1.06 (0.86-1.31) | .60 |
| Unknown | 1.15 (0.81-1.65) | .43 | 1.16 (0.81-1.65) | .43 |
| SEER region | ||||
| Northeast | 1.00 | 1.00 | ||
| Midwest | 0.96 (0.65-1.42) | .86 | 0.97 (0.65-1.43) | .86 |
| South | 0.97 (0.74-1.27) | .84 | 0.97 (0.74-1.27) | .84 |
| West | 1.09 (0.86-1.37) | .49 | 1.09 (0.86-1.37) | .49 |
| Elixhauser score | ||||
| 0 | 1.00 | 1.00 | ||
| 1-2 | 1.27 (1.03-1.57) | .03 | 1.27 (1.03-1.57) | .03 |
| ≥3 | 1.06 (0.79-1.43) | .70 | 1.06 (0.79-1.43) | .69 |
| Previous cancer | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.23 (1.00-1.51) | .05 | 1.23 (1.00-1.51) | .05 |
| Frailty | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.03 (0.80-1.32) | .84 | 1.03 (0.80-1.32) | .84 |
| Census tract Yost index | ||||
| Fifth quintile (highest SES) | 1.00 | 1.00 | ||
| Fourth quintile | 0.80 (0.62-1.04) | .09 | 0.80 (0.62-1.04) | .09 |
| Third quintile | 0.91 (0.68-1.22) | .53 | 0.91 (0.68-1.22) | .53 |
| Second quintile | 0.89 (0.65-1.22) | .46 | 0.89 (0.65-1.22) | .46 |
| First quintile (lowest SES) | 0.87 (0.60-1.27) | .47 | 0.87 (0.60-1.27) | .47 |
| Unknown | 0.92 (0.55-1.52) | .74 | 0.92 (0.55-1.52) | .74 |
| State buy-in | ||||
| No | 1.00 | 1.00 | ||
| Yes | 0.97 (0.72-1.29) | .82 | 0.97 (0.72-1.29) | .81 |
| Nonmetropolitan area | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.16 (0.88-1.52) | .29 | 1.16 (0.88-1.52) | .29 |
| . | Model 1, RUX (yes/no) . | Model 2, RUX PDC . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| RUX | ||||
| No | 1.00 | |||
| Yes | 0.96 (0.65-1.42) | .84 | ||
| PDC (per 10%) | 1.00 (0.96-1.05) | .95 | ||
| Previous HU | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.01 (0.83-1.24) | .91 | 1.01 (0.83-1.24) | .90 |
| Type of MPN | ||||
| PV | 1.00 | 1.00 | ||
| ET | 0.95 (0.78-1.16) | .60 | 0.95 (0.78-1.16) | .62 |
| MF | 0.91 (0.64-1.27) | .57 | 0.89 (0.63-1.25) | .50 |
| Age, y | ||||
| 66-69 | 1.00 | 1.00 | ||
| 70-74 | 0.99 (0.75-1.31) | .94 | 0.99 (0.75-1.31) | .94 |
| 75-79 | 1.10 (0.83-1.46) | .49 | 1.10 (0.83-1.46) | .49 |
| 80-84 | 0.83 (0.61-1.13) | .23 | 0.83 (0.61-1.13) | .23 |
| ≥85 | 0.62 (0.44-0.88) | <.01 | 0.62 (0.44-0.89) | <.01 |
| Sex | ||||
| Female | 1.00 | 1.00 | ||
| Male | 1.38 (1.14-1.67) | <.01 | 1.38 (1.14-1.67) | <.01 |
| Race | ||||
| White | 1.00 | 1.00 | ||
| Other | 0.80 (0.60-1.09) | .16 | 0.81 (0.60-1.09) | .16 |
| Marital status | ||||
| Married | 1.00 | 1.00 | ||
| Unmarried | 1.06 (0.86-1.31) | .60 | 1.06 (0.86-1.31) | .60 |
| Unknown | 1.15 (0.81-1.65) | .43 | 1.16 (0.81-1.65) | .43 |
| SEER region | ||||
| Northeast | 1.00 | 1.00 | ||
| Midwest | 0.96 (0.65-1.42) | .86 | 0.97 (0.65-1.43) | .86 |
| South | 0.97 (0.74-1.27) | .84 | 0.97 (0.74-1.27) | .84 |
| West | 1.09 (0.86-1.37) | .49 | 1.09 (0.86-1.37) | .49 |
| Elixhauser score | ||||
| 0 | 1.00 | 1.00 | ||
| 1-2 | 1.27 (1.03-1.57) | .03 | 1.27 (1.03-1.57) | .03 |
| ≥3 | 1.06 (0.79-1.43) | .70 | 1.06 (0.79-1.43) | .69 |
| Previous cancer | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.23 (1.00-1.51) | .05 | 1.23 (1.00-1.51) | .05 |
| Frailty | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.03 (0.80-1.32) | .84 | 1.03 (0.80-1.32) | .84 |
| Census tract Yost index | ||||
| Fifth quintile (highest SES) | 1.00 | 1.00 | ||
| Fourth quintile | 0.80 (0.62-1.04) | .09 | 0.80 (0.62-1.04) | .09 |
| Third quintile | 0.91 (0.68-1.22) | .53 | 0.91 (0.68-1.22) | .53 |
| Second quintile | 0.89 (0.65-1.22) | .46 | 0.89 (0.65-1.22) | .46 |
| First quintile (lowest SES) | 0.87 (0.60-1.27) | .47 | 0.87 (0.60-1.27) | .47 |
| Unknown | 0.92 (0.55-1.52) | .74 | 0.92 (0.55-1.52) | .74 |
| State buy-in | ||||
| No | 1.00 | 1.00 | ||
| Yes | 0.97 (0.72-1.29) | .82 | 0.97 (0.72-1.29) | .81 |
| Nonmetropolitan area | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.16 (0.88-1.52) | .29 | 1.16 (0.88-1.52) | .29 |
All variables in the table were mutually adjusted in the model.