MVA for OS
| IWG class . | IWG class incl. BM blasts . | ICC . | WHO5 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Class . | HR . | P value . | Class . | HR . | P value . | Entity . | HR . | P value . | Entity . | HR . | P value . |
| AML-like | 0.319 | .12 | AML-like | 0.277 | .09 | AML | 0.627 | .52 | AML | 0.542 | .30 |
| BCOR/L1 | 0.891 | .78 | BCOR/L1 | 0.835 | .68 | CMML1 | 0.768 | .26 | CMML1 | 0.871 | .55 |
| DDX41 | 0.663 | .39 | DDX41 | 0.577 | .26 | CMML2 | 2.644 | .018 | CMML2 | 3.460 | .0009 |
| EZH2-ASXL1 | 1.123 | .79 | EZH2-ASXL1 | 1.150 | .74 | MDS-EB | 0.954 | .82 | MDS-IB1 | 1.090 | .68 |
| IDH-STAG2 | 0.717 | .27 | IDH-STAG2 | 0.679 | .20 | MDS/AML | 1.112 | .65 | MDS-IB2 | 1.141 | .59 |
| No-event | 0.609 | .18 | No-event | 0.575 | .14 | MDS-SF3B1 | 0.237 | < .0001 | MDS-SF3B1 | 0.283 | < .0001 |
| −7/SETBP1 | 2.465 | .015 | −7/SETBP1 | 2.407 | .0180 | MDS-SLD | 0.607 | .11 | MDS-hypoplastic | 1.842 | .16 |
| SF3B1 | 0.266 | .0003 | SF3B1 | 0.271 | .0004 | MDS-TP53 | 3.353 | < .0001 | MDS–bi-TP53 | 4.307 | < .0001 |
| SRSF2 | 0.406 | .38 | SRSF2 | 0.406 | .38 | MDS-del5q | 0.393 | .02 | MDS-del5q | 0.484 | .07 |
| TP53-CK | 2.766 | .0002 | TP53-CK | 2.555 | .0008 | SCT | 0.291 | < .0001 | MDS-fibrosis | 1.366 | .55 |
| U2AF1-157 | 1.319 | .54 | U2AF1-157 | 1.283 | .58 | SCT | 0.289 | < .0001 | |||
| U2AF1-34 | 0.567 | .24 | U2AF1-34 | 0.548 | .20 | ||||||
| ZRSR2 | 3.347 | .06 | ZRSR2 | 3.452 | .05 | ||||||
| bi-TET2 | 0.479 | .0495 | bi-TET2 | 0.485 | .05 | ||||||
| Del(5q) | 0.363 | .015 | Del(5q) | 0.360 | .0147 | ||||||
| Der(1;7) | 0.532 | .54 | Der(1;7) | 0.530 | .53 | ||||||
| mNOS | 0.591 | .17 | mNOS | 0.600 | .18 | ||||||
| SCT | 0.295 | < .0001 | SCT | 0.277 | < .0001 | ||||||
| BM Blasts | 1.020 | .14 | |||||||||
| IWG class . | IWG class incl. BM blasts . | ICC . | WHO5 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Class . | HR . | P value . | Class . | HR . | P value . | Entity . | HR . | P value . | Entity . | HR . | P value . |
| AML-like | 0.319 | .12 | AML-like | 0.277 | .09 | AML | 0.627 | .52 | AML | 0.542 | .30 |
| BCOR/L1 | 0.891 | .78 | BCOR/L1 | 0.835 | .68 | CMML1 | 0.768 | .26 | CMML1 | 0.871 | .55 |
| DDX41 | 0.663 | .39 | DDX41 | 0.577 | .26 | CMML2 | 2.644 | .018 | CMML2 | 3.460 | .0009 |
| EZH2-ASXL1 | 1.123 | .79 | EZH2-ASXL1 | 1.150 | .74 | MDS-EB | 0.954 | .82 | MDS-IB1 | 1.090 | .68 |
| IDH-STAG2 | 0.717 | .27 | IDH-STAG2 | 0.679 | .20 | MDS/AML | 1.112 | .65 | MDS-IB2 | 1.141 | .59 |
| No-event | 0.609 | .18 | No-event | 0.575 | .14 | MDS-SF3B1 | 0.237 | < .0001 | MDS-SF3B1 | 0.283 | < .0001 |
| −7/SETBP1 | 2.465 | .015 | −7/SETBP1 | 2.407 | .0180 | MDS-SLD | 0.607 | .11 | MDS-hypoplastic | 1.842 | .16 |
| SF3B1 | 0.266 | .0003 | SF3B1 | 0.271 | .0004 | MDS-TP53 | 3.353 | < .0001 | MDS–bi-TP53 | 4.307 | < .0001 |
| SRSF2 | 0.406 | .38 | SRSF2 | 0.406 | .38 | MDS-del5q | 0.393 | .02 | MDS-del5q | 0.484 | .07 |
| TP53-CK | 2.766 | .0002 | TP53-CK | 2.555 | .0008 | SCT | 0.291 | < .0001 | MDS-fibrosis | 1.366 | .55 |
| U2AF1-157 | 1.319 | .54 | U2AF1-157 | 1.283 | .58 | SCT | 0.289 | < .0001 | |||
| U2AF1-34 | 0.567 | .24 | U2AF1-34 | 0.548 | .20 | ||||||
| ZRSR2 | 3.347 | .06 | ZRSR2 | 3.452 | .05 | ||||||
| bi-TET2 | 0.479 | .0495 | bi-TET2 | 0.485 | .05 | ||||||
| Del(5q) | 0.363 | .015 | Del(5q) | 0.360 | .0147 | ||||||
| Der(1;7) | 0.532 | .54 | Der(1;7) | 0.530 | .53 | ||||||
| mNOS | 0.591 | .17 | mNOS | 0.600 | .18 | ||||||
| SCT | 0.295 | < .0001 | SCT | 0.277 | < .0001 | ||||||
| BM Blasts | 1.020 | .14 | |||||||||
The analyses included SCT as a time-dependent variable for IWG class (left columns), ICC MDS entities (middle columns), and WHO5 MDS entities (right columns). BM blasts at diagnosis as a continuous variable were also included for the IWG analysis. Statistically significant entities within each classification are bolded. Reference groups: IWG: CCUS-like, ICC: MDS-MLD, WHO5: MDS-LB.