Baseline laboratory findings, VL, and cytokine levels for participants with KICS compared with those with PEL with or without KS, MCD with KS, and KS alone
| Laboratory findings, VL, and HLH score . | KICS ± KS . | PEL ± KS . | P value . | MCD + KS . | P value . | KS alone . | P value . |
|---|---|---|---|---|---|---|---|
| Hemoglobin, median (IQR), g/dL | 9.4 (8.1-10.7) | 9.3 (7.9-9.9) | .43 | 9.0 (8.0-10.4) | .59 | 13.8 (13.1-14.8) | <.0001 |
| Platelets, median (IQR), K/μL | 230 (148-317) | 207 (122.5-327.5) | .44 | 70 (51-141) | <.0001 | 247 (204-272) | .91 |
| Albumin, median (IQR), g/dL | 3.1 (2.4-3.6) | 2.6 (2.2-3) | .03 | 2.6 (1.7-2.9) | .01 | 3.9 (3.5-4.2) | .0007 |
| C-reactive protein, median (IQR), mg/L | 37.0 (9.5-62.5) | 32.1 (16.3-72.9) | .48 | 106 (61.5-172) | .004 | 3.9 (2.2-11.6) | .0001 |
| Ferritin, median (IQR), μg/L | 399.5 (200.5-791.5) | 786.5 (560-1959) | .01 | 1815.5 (457.5-2959.8) | .02 | 195.5 (105.8-320) | .17 |
| Triglycerides, median (IQR), mg/dL | 137 (103-186) | 190 (143-213) | .02 | 180 (128-211) | .30 | 325 (258.3-369.3) | .006 |
| Fibrinogen, median (IQR), mg/dL | 403 (340-514) | 416 (315-459) | .64 | 434 (318-528) | .99 | 349 (312-421) | .17 |
| H-score, median (IQR), points | 62 (39-91) | 81 (62-116) | .10 | 108 (86-156) | .003 | 18 (18-59) | .01 |
| Cytokine levels at baseline | |||||||
| IL-1β, median (IQR), pg/mL | 0.2 (0.2-0.3) | 0.2 (0.2-0.3) | .74 | 0.2 (0.2-0.4) | .80 | 0.1 (0.1-0.2) | .002 |
| IL-6, median (IQR), pg/mL | 6.4 (2.2-11.9) | 5.6 (3.2-12.4) | .71 | 11.8 (6.9-19.7) | .02 | 1.4 (0.7-1.7) | <.0001 |
| IL-10, median (IQR), pg/mL | 3.3 (1.8-7.8) | 29.9 (8.7-104.4) | .002 | 284.3 (41.8-1382.0) | .0003 | 0.6 (0.4-1.4) | <.0001 |
| IL-12, median (IQR), pg/mL | 0.2 (0.2-0.3) | 0.3 (0.2-0.4) | .65 | 0.2 (0.1-0.4) | .34 | 0.2 (0.1-0.3) | .08 |
| IL-18, median (IQR), pg/mL | 1770.9 (1278.5-2607.4) | 3359.5 (2185.1-4671.1) | .003 | 5169.1 (3258.0-13 065.8) | .0001 | 1476.5 (1370.4-2386.5) | .92 |
| IFN-γ, median (IQR), pg/mL | 11.2 (7.2-49.3) | 24.2 (17.1-68.8) | .07 | 32.9 (19.0-131.2) | .02 | 12.7 (5.0-14.7) | .25 |
| TNF-α, median (IQR), pg/mL | 4.1 (3.2-5.1) | 5.7 (4.2-6.9) | .02 | 8.2 (6.9-12.1) | <.0001 | 3.5 (1.6-5.3) | .36 |
| KSHV VL | |||||||
| KSHV VL in PBMCs, median (IQR), copies per 106 cells | 882 (35-3574) | 1792 (372-13 263) | .11 | 33091 (4545-255 319) | .0003 | 0 (0-0) | .0001 |
| Laboratory findings, VL, and HLH score . | KICS ± KS . | PEL ± KS . | P value . | MCD + KS . | P value . | KS alone . | P value . |
|---|---|---|---|---|---|---|---|
| Hemoglobin, median (IQR), g/dL | 9.4 (8.1-10.7) | 9.3 (7.9-9.9) | .43 | 9.0 (8.0-10.4) | .59 | 13.8 (13.1-14.8) | <.0001 |
| Platelets, median (IQR), K/μL | 230 (148-317) | 207 (122.5-327.5) | .44 | 70 (51-141) | <.0001 | 247 (204-272) | .91 |
| Albumin, median (IQR), g/dL | 3.1 (2.4-3.6) | 2.6 (2.2-3) | .03 | 2.6 (1.7-2.9) | .01 | 3.9 (3.5-4.2) | .0007 |
| C-reactive protein, median (IQR), mg/L | 37.0 (9.5-62.5) | 32.1 (16.3-72.9) | .48 | 106 (61.5-172) | .004 | 3.9 (2.2-11.6) | .0001 |
| Ferritin, median (IQR), μg/L | 399.5 (200.5-791.5) | 786.5 (560-1959) | .01 | 1815.5 (457.5-2959.8) | .02 | 195.5 (105.8-320) | .17 |
| Triglycerides, median (IQR), mg/dL | 137 (103-186) | 190 (143-213) | .02 | 180 (128-211) | .30 | 325 (258.3-369.3) | .006 |
| Fibrinogen, median (IQR), mg/dL | 403 (340-514) | 416 (315-459) | .64 | 434 (318-528) | .99 | 349 (312-421) | .17 |
| H-score, median (IQR), points | 62 (39-91) | 81 (62-116) | .10 | 108 (86-156) | .003 | 18 (18-59) | .01 |
| Cytokine levels at baseline | |||||||
| IL-1β, median (IQR), pg/mL | 0.2 (0.2-0.3) | 0.2 (0.2-0.3) | .74 | 0.2 (0.2-0.4) | .80 | 0.1 (0.1-0.2) | .002 |
| IL-6, median (IQR), pg/mL | 6.4 (2.2-11.9) | 5.6 (3.2-12.4) | .71 | 11.8 (6.9-19.7) | .02 | 1.4 (0.7-1.7) | <.0001 |
| IL-10, median (IQR), pg/mL | 3.3 (1.8-7.8) | 29.9 (8.7-104.4) | .002 | 284.3 (41.8-1382.0) | .0003 | 0.6 (0.4-1.4) | <.0001 |
| IL-12, median (IQR), pg/mL | 0.2 (0.2-0.3) | 0.3 (0.2-0.4) | .65 | 0.2 (0.1-0.4) | .34 | 0.2 (0.1-0.3) | .08 |
| IL-18, median (IQR), pg/mL | 1770.9 (1278.5-2607.4) | 3359.5 (2185.1-4671.1) | .003 | 5169.1 (3258.0-13 065.8) | .0001 | 1476.5 (1370.4-2386.5) | .92 |
| IFN-γ, median (IQR), pg/mL | 11.2 (7.2-49.3) | 24.2 (17.1-68.8) | .07 | 32.9 (19.0-131.2) | .02 | 12.7 (5.0-14.7) | .25 |
| TNF-α, median (IQR), pg/mL | 4.1 (3.2-5.1) | 5.7 (4.2-6.9) | .02 | 8.2 (6.9-12.1) | <.0001 | 3.5 (1.6-5.3) | .36 |
| KSHV VL | |||||||
| KSHV VL in PBMCs, median (IQR), copies per 106 cells | 882 (35-3574) | 1792 (372-13 263) | .11 | 33091 (4545-255 319) | .0003 | 0 (0-0) | .0001 |
IQR, interquartile range.