Baseline characteristics by disease state and t(11;14) positivity
| . | NDMM . | RRMM . | Total (n = 525) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| t(11;14) positive (n = 56) . | t(11;14) negative (n = 235) . | t(11;14) indeterminate (n = 7) . | t(11;14) test failure (n = 8) . | t(11;14) positive (n = 54) . | t(11;14) negative (n = 141) . | t(11;14) indeterminate (n = 5) . | t(11;14) test failure (n = 19) . | ||
| Median age (range), y | 64.0 (37.0-88.0) | 66.0 (37.0-90.0) | 55.0 (41.0-78.0) | 54.5 (42.0-76.0) | 63.0 (44.0-89.0) | 67.0 (45.0-88.0) | 65.0 (52.0-77.0) | 72.0 (41.0-92.0) | 66.0 (37.0-92.0) |
| Sex, n (%) | |||||||||
| Male | 31 (55) | 120 (51) | 2 (29) | 5 (63) | 35 (65) | 83 (59) | 3 (60) | 12 (63) | 291 (55) |
| Female | 25 (45) | 115 (49) | 5 (71) | 3 (38) | 19 (35) | 58 (41) | 2 (40) | 7 (37) | 234 (45) |
| Race/ethnicity, n (%) | |||||||||
| Asian | 1 (2) | 9 (4) | - | 1 (13) | - | 6 (4) | - | - | 17 (3) |
| Black or African American | 2 (4) | - | - | - | 9 (17) | 6 (4) | - | - | 17 (3) |
| White | 45 (80) | 183 (78) | 2 (29) | 6 (75) | 37 (69) | 102 (72) | 3 (60) | 13 (68) | 391 (74) |
| Hispanic or Latino | 5 (9) | 27 (11) | 2 (29) | - | 6 (11) | 18 (13) | 2 (40) | 5 (26) | 65 (12) |
| Unknown | 3 (5) | 16 (7) | 3 (43) | 1 (13) | 2 (4) | 9 (6) | - | 1 (5) | 35 (7) |
| ECOG PS, n (%) | |||||||||
| ≤2 | 45 (80) | 196 (83) | 7 (100) | 8 (100) | 49 (91) | 110 (78) | 5 (100) | 17 (89) | 437 (83) |
| >2 | 4 (7) | 8 (3) | - | - | - | 3 (2) | - | - | 15 (3) |
| Unknown | 7 (13) | 31 (13) | - | - | 5 (9) | 28 (20) | - | 2 (11) | 73 (14) |
| Disease stage, n (%) | |||||||||
| I | 18 (32) | 65 (28) | 1 (14) | 3 (38) | 20 (37) | 51 (36) | 3 (60) | 5 (26) | 166 (32) |
| II | 17 (30) | 64 (27) | 3 (43) | 2 (25) | 7 (13) | 29 (21) | - | 3 (16) | 125 (24) |
| III | 14 (25) | 66 (28) | 2 (29) | 2 (25) | 12 (22) | 28 (20) | - | 7 (37) | 131 (25) |
| Unknown | 7 (13) | 40 (17) | 1 (14) | 1 (13) | 15 (28) | 33 (23) | 2 (40) | 4 (21) | 103 (20) |
| Measurable disease, n (%) | |||||||||
| IgG | 27 (48) | 148 (63) | 3 (43) | 4 (50) | 27 (50) | 78 (55) | 3 (60) | 11 (58) | 301 (57) |
| IgA | 10 (18) | 44 (19) | 2 (29) | 1 (13) | 8 (15) | 25 (18) | - | 6 (32) | 96 (18) |
| Light chain only | 17 (30) | 45 (19) | 3 (43) | 3 (38) | 17 (31) | 25 (18) | 2 (40) | 5 (26) | 117 (22) |
| No detectable M protein (or nonsecretory MM) | 5 (9) | 3 (1) | - | 1 (13) | 2 (4) | 2 (1) | - | 2 (11) | 15 (3) |
| Other | 1 (2) | 7 (3) | - | - | 4 (7) | 11 (8) | - | - | 23 (4) |
| Unknown | 4 (7) | 18 (8) | 1 (14) | - | 4 (7) | 15 (11) | - | 1 (5) | 43 (8) |
| Chromosome 17/17p, n (%) | |||||||||
| Deleted | 8 (14) | 35 (15) | - | - | 7 (13) | 16 (11) | - | 1 (5) | 67 (13) |
| Not deleted | 24 (43) | 106 (45) | 1 (14) | 3 (38) | 24 (44) | 53 (38) | 1 (20) | 7 (37) | 219 (42) |
| Unknown/not tested | 24 (43) | 94 (40) | 6 (86) | 5 (63) | 23 (43) | 72 (51) | 4 (80) | 11 (58) | 239 (46) |
| Chromosome 1/1q | |||||||||
| Gain (≥3 copies) | 7 (13) | 45 (19) | 1 (14) | - | 10 (19) | 22 (16) | - | - | 85 (16) |
| No gain | 22 (39) | 96 (41) | 3 (43) | 2 (25) | 16 (30) | 34 (24) | - | 2 (11) | 175 (33) |
| Unknown/not tested | 27 (48) | 94 (40) | 3 (43) | 6 (75) | 28 (52) | 85 (60) | 5 (100) | 17 (89) | 265 (50) |
| . | NDMM . | RRMM . | Total (n = 525) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| t(11;14) positive (n = 56) . | t(11;14) negative (n = 235) . | t(11;14) indeterminate (n = 7) . | t(11;14) test failure (n = 8) . | t(11;14) positive (n = 54) . | t(11;14) negative (n = 141) . | t(11;14) indeterminate (n = 5) . | t(11;14) test failure (n = 19) . | ||
| Median age (range), y | 64.0 (37.0-88.0) | 66.0 (37.0-90.0) | 55.0 (41.0-78.0) | 54.5 (42.0-76.0) | 63.0 (44.0-89.0) | 67.0 (45.0-88.0) | 65.0 (52.0-77.0) | 72.0 (41.0-92.0) | 66.0 (37.0-92.0) |
| Sex, n (%) | |||||||||
| Male | 31 (55) | 120 (51) | 2 (29) | 5 (63) | 35 (65) | 83 (59) | 3 (60) | 12 (63) | 291 (55) |
| Female | 25 (45) | 115 (49) | 5 (71) | 3 (38) | 19 (35) | 58 (41) | 2 (40) | 7 (37) | 234 (45) |
| Race/ethnicity, n (%) | |||||||||
| Asian | 1 (2) | 9 (4) | - | 1 (13) | - | 6 (4) | - | - | 17 (3) |
| Black or African American | 2 (4) | - | - | - | 9 (17) | 6 (4) | - | - | 17 (3) |
| White | 45 (80) | 183 (78) | 2 (29) | 6 (75) | 37 (69) | 102 (72) | 3 (60) | 13 (68) | 391 (74) |
| Hispanic or Latino | 5 (9) | 27 (11) | 2 (29) | - | 6 (11) | 18 (13) | 2 (40) | 5 (26) | 65 (12) |
| Unknown | 3 (5) | 16 (7) | 3 (43) | 1 (13) | 2 (4) | 9 (6) | - | 1 (5) | 35 (7) |
| ECOG PS, n (%) | |||||||||
| ≤2 | 45 (80) | 196 (83) | 7 (100) | 8 (100) | 49 (91) | 110 (78) | 5 (100) | 17 (89) | 437 (83) |
| >2 | 4 (7) | 8 (3) | - | - | - | 3 (2) | - | - | 15 (3) |
| Unknown | 7 (13) | 31 (13) | - | - | 5 (9) | 28 (20) | - | 2 (11) | 73 (14) |
| Disease stage, n (%) | |||||||||
| I | 18 (32) | 65 (28) | 1 (14) | 3 (38) | 20 (37) | 51 (36) | 3 (60) | 5 (26) | 166 (32) |
| II | 17 (30) | 64 (27) | 3 (43) | 2 (25) | 7 (13) | 29 (21) | - | 3 (16) | 125 (24) |
| III | 14 (25) | 66 (28) | 2 (29) | 2 (25) | 12 (22) | 28 (20) | - | 7 (37) | 131 (25) |
| Unknown | 7 (13) | 40 (17) | 1 (14) | 1 (13) | 15 (28) | 33 (23) | 2 (40) | 4 (21) | 103 (20) |
| Measurable disease, n (%) | |||||||||
| IgG | 27 (48) | 148 (63) | 3 (43) | 4 (50) | 27 (50) | 78 (55) | 3 (60) | 11 (58) | 301 (57) |
| IgA | 10 (18) | 44 (19) | 2 (29) | 1 (13) | 8 (15) | 25 (18) | - | 6 (32) | 96 (18) |
| Light chain only | 17 (30) | 45 (19) | 3 (43) | 3 (38) | 17 (31) | 25 (18) | 2 (40) | 5 (26) | 117 (22) |
| No detectable M protein (or nonsecretory MM) | 5 (9) | 3 (1) | - | 1 (13) | 2 (4) | 2 (1) | - | 2 (11) | 15 (3) |
| Other | 1 (2) | 7 (3) | - | - | 4 (7) | 11 (8) | - | - | 23 (4) |
| Unknown | 4 (7) | 18 (8) | 1 (14) | - | 4 (7) | 15 (11) | - | 1 (5) | 43 (8) |
| Chromosome 17/17p, n (%) | |||||||||
| Deleted | 8 (14) | 35 (15) | - | - | 7 (13) | 16 (11) | - | 1 (5) | 67 (13) |
| Not deleted | 24 (43) | 106 (45) | 1 (14) | 3 (38) | 24 (44) | 53 (38) | 1 (20) | 7 (37) | 219 (42) |
| Unknown/not tested | 24 (43) | 94 (40) | 6 (86) | 5 (63) | 23 (43) | 72 (51) | 4 (80) | 11 (58) | 239 (46) |
| Chromosome 1/1q | |||||||||
| Gain (≥3 copies) | 7 (13) | 45 (19) | 1 (14) | - | 10 (19) | 22 (16) | - | - | 85 (16) |
| No gain | 22 (39) | 96 (41) | 3 (43) | 2 (25) | 16 (30) | 34 (24) | - | 2 (11) | 175 (33) |
| Unknown/not tested | 27 (48) | 94 (40) | 3 (43) | 6 (75) | 28 (52) | 85 (60) | 5 (100) | 17 (89) | 265 (50) |
-, not applicable.