Test diagnostic performance
| Parameter (N = 113) . | ELISA Positive threshold: 0.5 . | CLIA Positive threshold: 1 . | ELISA Positive threshold: 0.3 . | CLIA Positive threshold: 0.8 . |
|---|---|---|---|---|
| Specificity, TN/(TN + FP), % (95% CI) | 74.3 (64.0-84.5) | 80.0 (70.6-89.3) | 68.6 (57.7-79.4) | 77.1 (67.3-87.0) |
| Sensitivity, TP/(TP + FN), % (95% CI) | 95.3 (89.1-100.0) | 90.7 (82.0-99.4) | 95.3 (89.1-100.0) | 93.0 (85.4-100.0) |
| NPV, % (95% CI) | 96.3 (91.3-100.0) | 93.3 (87.0-99.6) | 96.0 (90.6-100.0) | 94.7 (88.9-100.0) |
| PPV, % (95% CI) | 69.5 (57.7-81.2) | 73.6 (61.7-85.5) | 65.1 (53.3-76.9) | 71.4 (59.6-83.3) |
| TN, n | 52 | 56 | 48 | 54 |
| FP, n | 18 | 14 | 22 | 16 |
| TP, n | 41 | 39 | 41 | 40 |
| FN, n | 2 | 4 | 2 | 3 |
| Parameter (N = 113) . | ELISA Positive threshold: 0.5 . | CLIA Positive threshold: 1 . | ELISA Positive threshold: 0.3 . | CLIA Positive threshold: 0.8 . |
|---|---|---|---|---|
| Specificity, TN/(TN + FP), % (95% CI) | 74.3 (64.0-84.5) | 80.0 (70.6-89.3) | 68.6 (57.7-79.4) | 77.1 (67.3-87.0) |
| Sensitivity, TP/(TP + FN), % (95% CI) | 95.3 (89.1-100.0) | 90.7 (82.0-99.4) | 95.3 (89.1-100.0) | 93.0 (85.4-100.0) |
| NPV, % (95% CI) | 96.3 (91.3-100.0) | 93.3 (87.0-99.6) | 96.0 (90.6-100.0) | 94.7 (88.9-100.0) |
| PPV, % (95% CI) | 69.5 (57.7-81.2) | 73.6 (61.7-85.5) | 65.1 (53.3-76.9) | 71.4 (59.6-83.3) |
| TN, n | 52 | 56 | 48 | 54 |
| FP, n | 18 | 14 | 22 | 16 |
| TP, n | 41 | 39 | 41 | 40 |
| FN, n | 2 | 4 | 2 | 3 |
FN, false negative; FP, false positive; TN, true negative; TP, true positive.