Any-grade and grade ≥3 TEAEs occurring in 15% or more of all patients with R/R FL, and TRAEs
| Preferred Term . | TEAEs in patients with FL (N = 48) . | |||
|---|---|---|---|---|
| All-cause AEs (≥15%), % . | TRAEs, % . | |||
| AE | Any grade | Grade ≥3 | Any grade | Grade ≥3 |
| Diarrhea | 29.2 | 2.1 | 8.3 | 0 |
| Fatigue | 25.0 | 4.2 | 14.6 | 0 |
| Nausea | 22.9 | 2.1 | 12.5 | 2.1 |
| Arthralgia | 18.8 | 0 | 8.3 | 0 |
| Back pain | 18.8 | 0 | 0 | 0 |
| Neutropenia∗ | 16.7 | 14.6 | 10.4 | 8.3 |
| AEs of interest† | Any grade | Grade ≥3 | Any grade | Grade ≥3 |
| Infections‡ | 56.3 | 18.8 | 12.5 | 0 |
| Rash§ | 14.6 | 2.1 | 8.3 | 2.1 |
| Bruising‖ | 10.4 | 0 | 2.1 | 0 |
| Hemorrhage¶ | 6.3 | 0 | 2.1 | 0 |
| Hypertension | 6.3 | 2.1 | 0 | 0 |
| Atrial fibrillation/flutter# | 2.1 | 0 | 2.1 | 0 |
| Preferred Term . | TEAEs in patients with FL (N = 48) . | |||
|---|---|---|---|---|
| All-cause AEs (≥15%), % . | TRAEs, % . | |||
| AE | Any grade | Grade ≥3 | Any grade | Grade ≥3 |
| Diarrhea | 29.2 | 2.1 | 8.3 | 0 |
| Fatigue | 25.0 | 4.2 | 14.6 | 0 |
| Nausea | 22.9 | 2.1 | 12.5 | 2.1 |
| Arthralgia | 18.8 | 0 | 8.3 | 0 |
| Back pain | 18.8 | 0 | 0 | 0 |
| Neutropenia∗ | 16.7 | 14.6 | 10.4 | 8.3 |
| AEs of interest† | Any grade | Grade ≥3 | Any grade | Grade ≥3 |
| Infections‡ | 56.3 | 18.8 | 12.5 | 0 |
| Rash§ | 14.6 | 2.1 | 8.3 | 2.1 |
| Bruising‖ | 10.4 | 0 | 2.1 | 0 |
| Hemorrhage¶ | 6.3 | 0 | 2.1 | 0 |
| Hypertension | 6.3 | 2.1 | 0 | 0 |
| Atrial fibrillation/flutter# | 2.1 | 0 | 2.1 | 0 |
Data cutoff of 27 January 2025.
Aggregate of neutropenia and neutrophil count decreased.
AEs of interest are those that were previously associated with cBTKis.
Aggregate of all preferred terms indicating infection and including COVID-19.
Aggregate of all preferred terms indicating rash.
Aggregate of contusion, eye contusion, and increased tendency to bruise.
Aggregate of all preferred terms including hemorrhage or hematoma.
Aggregate of atrial fibrillation and atrial flutter.