Frequency of detection of circulating EBV DNA in plasma and median log10 EBV copies per milliliter among cases of BL and controls
| Characteristics . | Cases of BL . | Controls . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. EBV positive/no. tested . | EBV positive (row %) . | Median . | P value for median∗ . | No. EBV positive/no. tested . | EBV positive (row %) . | Median . | P value for median∗ . | |
| All participants | 309/400 | 77.3 | 5.38 | — | 62/400 | 15.5 | 1.74 | — |
| Sex | ||||||||
| Male | 203/252 | 80.6 | 5.20 | .0118 | 38/256 | 14.8 | 1.75 | .2905 |
| Female | 106/148 | 71.6 | 5.62 | 24/144 | 16.7 | 1.73 | ||
| Age group, y | ||||||||
| 0-2 | 15/25 | 60.0 | 2.22 | .0004 | 3/20 | 15.0 | 2.23 | .4722 |
| 3-5 | 84/104 | 80.8 | 5.25 | 20/103 | 19.4 | 1.76 | ||
| 6-8 | 99/123 | 80.5 | 5.41 | 23/122 | 18.9 | 1.75 | ||
| 9-11 | 69/88 | 78.4 | 5.73 | 12/93 | 12.9 | 1.72 | ||
| 12-15 | 42/60 | 70.0 | 5.40 | 4/62 | 6.5 | 1.91 | ||
| Country | ||||||||
| Kenya | 100/148 | 67.6 | 4.64 | .0001 | 21/133 | 15.8 | 1.53 | .7611 |
| Tanzania | 39/48 | 81.3 | 5.14 | 4/50 | 8.0 | 1.91 | ||
| Uganda | 170/204 | 83.3 | 5.73 | 37/217 | 17.1 | 1.74 | ||
| Urban/rural status of home | ||||||||
| Urban | 106/142 | 74.7 | 5.51 | .9041 | 15/144 | 10.4 | 1.71 | .9611 |
| Rural | 160/198 | 80.8 | 5.37 | 47/256 | 18.4 | 1.74 | ||
| Proximity of home to surface water | ||||||||
| Far from water | 54/65 | 83.1 | 5.32 | .1980 | 23/176 | 13.1 | 1.75 | .8851 |
| Near water | 211/274 | 77.0 | 5.41 | 39/224 | 17.4 | 1.74 | ||
| Season of enrollment | ||||||||
| Wet | 176/232 | 75.9 | 5.47 | .3763 | 31/216 | 14.4 | 1.72 | .2067 |
| Dry | 133/168 | 79.2 | 5.21 | 31/184 | 16.9 | 1.99 | ||
| P falciparum infection status | ||||||||
| Negative | 227/298 | 76.2 | 5.39 | .5041 | 24/222 | 10.8 | 1.48 | .0713 |
| Recent | 20/26 | 76.9 | 5.68 | 4/54 | 7.4 | 1.90 | ||
| Current | 58/71 | 81.7 | 4.98 | 34/123 | 27.6 | 1.84 | ||
| RPP30 detection | ||||||||
| Positive | 288/329 | 87.5 | 5.38 | .8891 | 59/336 | 17.6 | 1.74 | .7808 |
| Negative | 21/71 | 29.6 | 5.36 | 3/64 | 4.7 | 1.50 | ||
| Tumor anatomic site involvement | ||||||||
| Head only | 99/127 | 78.0 | 4.88 | .0001 | NA | NA | NA | |
| Head and abdomen and abdomen only | 177/235 | 75.3 | 5.73 | |||||
| Other and disseminated | 11/13 | 84.6 | 5.91 | |||||
| Characteristics . | Cases of BL . | Controls . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. EBV positive/no. tested . | EBV positive (row %) . | Median . | P value for median∗ . | No. EBV positive/no. tested . | EBV positive (row %) . | Median . | P value for median∗ . | |
| All participants | 309/400 | 77.3 | 5.38 | — | 62/400 | 15.5 | 1.74 | — |
| Sex | ||||||||
| Male | 203/252 | 80.6 | 5.20 | .0118 | 38/256 | 14.8 | 1.75 | .2905 |
| Female | 106/148 | 71.6 | 5.62 | 24/144 | 16.7 | 1.73 | ||
| Age group, y | ||||||||
| 0-2 | 15/25 | 60.0 | 2.22 | .0004 | 3/20 | 15.0 | 2.23 | .4722 |
| 3-5 | 84/104 | 80.8 | 5.25 | 20/103 | 19.4 | 1.76 | ||
| 6-8 | 99/123 | 80.5 | 5.41 | 23/122 | 18.9 | 1.75 | ||
| 9-11 | 69/88 | 78.4 | 5.73 | 12/93 | 12.9 | 1.72 | ||
| 12-15 | 42/60 | 70.0 | 5.40 | 4/62 | 6.5 | 1.91 | ||
| Country | ||||||||
| Kenya | 100/148 | 67.6 | 4.64 | .0001 | 21/133 | 15.8 | 1.53 | .7611 |
| Tanzania | 39/48 | 81.3 | 5.14 | 4/50 | 8.0 | 1.91 | ||
| Uganda | 170/204 | 83.3 | 5.73 | 37/217 | 17.1 | 1.74 | ||
| Urban/rural status of home | ||||||||
| Urban | 106/142 | 74.7 | 5.51 | .9041 | 15/144 | 10.4 | 1.71 | .9611 |
| Rural | 160/198 | 80.8 | 5.37 | 47/256 | 18.4 | 1.74 | ||
| Proximity of home to surface water | ||||||||
| Far from water | 54/65 | 83.1 | 5.32 | .1980 | 23/176 | 13.1 | 1.75 | .8851 |
| Near water | 211/274 | 77.0 | 5.41 | 39/224 | 17.4 | 1.74 | ||
| Season of enrollment | ||||||||
| Wet | 176/232 | 75.9 | 5.47 | .3763 | 31/216 | 14.4 | 1.72 | .2067 |
| Dry | 133/168 | 79.2 | 5.21 | 31/184 | 16.9 | 1.99 | ||
| P falciparum infection status | ||||||||
| Negative | 227/298 | 76.2 | 5.39 | .5041 | 24/222 | 10.8 | 1.48 | .0713 |
| Recent | 20/26 | 76.9 | 5.68 | 4/54 | 7.4 | 1.90 | ||
| Current | 58/71 | 81.7 | 4.98 | 34/123 | 27.6 | 1.84 | ||
| RPP30 detection | ||||||||
| Positive | 288/329 | 87.5 | 5.38 | .8891 | 59/336 | 17.6 | 1.74 | .7808 |
| Negative | 21/71 | 29.6 | 5.36 | 3/64 | 4.7 | 1.50 | ||
| Tumor anatomic site involvement | ||||||||
| Head only | 99/127 | 78.0 | 4.88 | .0001 | NA | NA | NA | |
| Head and abdomen and abdomen only | 177/235 | 75.3 | 5.73 | |||||
| Other and disseminated | 11/13 | 84.6 | 5.91 | |||||
NA, not applicable.
The P value is from either the 2-sample Wilcoxon rank-sum test or Kruskal-Wallis quality-of-populations rank test, as appropriate. P value font is bold when statistically signficant.