Table 1.

Clinical and laboratory characteristics of patients with CML at diagnosis and at asciminib initiation (n = 34)

Variablesn (%)
Age at diagnosis, median (range), y 44.5 (6-74) 
Age at asciminib initiation, median (range), y 51.5 (14-78) 
Sex, male 22 (64.7) 
CML phase at diagnosis  
Chronic 31 (91.2) 
Accelerated 3 (8.8) 
CML phase at asciminib initiation  
Chronic 26 (83) 
Accelerated 4 (12.5) 
BC 2 (6) 
Sokal score (diagnosis)  
Low 7 (20.6) 
Intermediate 8 (23.5) 
High 9 (26.5) 
Missing 10 (29.4) 
ELTS score (diagnosis)  
Low 11 (32.4) 
Intermediate 14 (43) 
High 5 (14.7) 
Missing 7 (20.6) 
BCR::ABL1 mutations  
No mutations 20 (58.8) 
T315I 7 (20.5) 
Other mutations  6 (18) 
Not analyzed 1 (2.9) 
ACAs at asciminib initiation  
No ACAs 16 (47) 
Not available 17 (50) 
Missing 1 (3) 
Baseline BCR::ABL1 transcripts % IS (before asciminib), median (range) 25 (0.1-184) 
Previous therapeutics lines  
2-3 29 (85.3) 
≥4  5 (14.7) 
Variablesn (%)
Age at diagnosis, median (range), y 44.5 (6-74) 
Age at asciminib initiation, median (range), y 51.5 (14-78) 
Sex, male 22 (64.7) 
CML phase at diagnosis  
Chronic 31 (91.2) 
Accelerated 3 (8.8) 
CML phase at asciminib initiation  
Chronic 26 (83) 
Accelerated 4 (12.5) 
BC 2 (6) 
Sokal score (diagnosis)  
Low 7 (20.6) 
Intermediate 8 (23.5) 
High 9 (26.5) 
Missing 10 (29.4) 
ELTS score (diagnosis)  
Low 11 (32.4) 
Intermediate 14 (43) 
High 5 (14.7) 
Missing 7 (20.6) 
BCR::ABL1 mutations  
No mutations 20 (58.8) 
T315I 7 (20.5) 
Other mutations  6 (18) 
Not analyzed 1 (2.9) 
ACAs at asciminib initiation  
No ACAs 16 (47) 
Not available 17 (50) 
Missing 1 (3) 
Baseline BCR::ABL1 transcripts % IS (before asciminib), median (range) 25 (0.1-184) 
Previous therapeutics lines  
2-3 29 (85.3) 
≥4  5 (14.7) 

ACA, additional cytogenetic abnormality; ELTS, European Treatment and Outcome Study long-term survival; IS, international scale.

E255K mutation, n = 1; E255V/F317L mutation, n = 1; F359V mutation, n = 1; and exon 7 deletion, n = 3.

Two patients had previous HSCT.

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