Definition of DLTs
| Adverse event . | Definitions . |
|---|---|
| CRS | Grade ≥4 or grade 3 >7 days |
| ICANS | Grade ≥4 or grade 3 >72 hours |
| Infusion reaction | Grade ≥4 |
| Nonhematologic organ toxicities | Grade ≥3 involving vital organs that fail to resolve to grade ≤2 within 7 days if not preexisting and not attributable to underlying disease |
| Adverse event . | Definitions . |
|---|---|
| CRS | Grade ≥4 or grade 3 >7 days |
| ICANS | Grade ≥4 or grade 3 >72 hours |
| Infusion reaction | Grade ≥4 |
| Nonhematologic organ toxicities | Grade ≥3 involving vital organs that fail to resolve to grade ≤2 within 7 days if not preexisting and not attributable to underlying disease |