Table 2.

Hematological parameters of Townes mice transduced with 2 × 1013 vg/kg rAAV8-hHPX or 1 × 1014 vg/kg rAAV8-mHPX vector compared with mice treated with the control vector

rAAV8-mHPX (n = 16)rAAV8-Empty (n = 10)P value 
28th Week 
Leukocytes (×103/μL) 12.0 (8.5-14.4) 12.1 (9.4-17.2) .84 
Hb (g/dL) 4.5 (4.0-5.5) 4.5 (4.2-6.2) .36 
Platelets (×103/μL) 810 (573-1063) 865 (735-1090) .46 
rAAV8-mHPX (n = 16)rAAV8-Empty (n = 10)P value 
28th Week 
Leukocytes (×103/μL) 12.0 (8.5-14.4) 12.1 (9.4-17.2) .84 
Hb (g/dL) 4.5 (4.0-5.5) 4.5 (4.2-6.2) .36 
Platelets (×103/μL) 810 (573-1063) 865 (735-1090) .46 
rAAV8-hHPX (n = 7)rAAV8-Empty (n = 3)P value 
34th Week 
Leukocytes (×103/μL) 7.1 (4.1-9.0) 10.1 (5.0-18.7) .47 
Hb (g/dL) 4.2 (3.2-5.6) 4.0 (2.3-5.2) .77 
Platelets (×103/μL) 392 (302-698) 455 (235-663) .91 
rAAV8-hHPX (n = 7)rAAV8-Empty (n = 3)P value 
34th Week 
Leukocytes (×103/μL) 7.1 (4.1-9.0) 10.1 (5.0-18.7) .47 
Hb (g/dL) 4.2 (3.2-5.6) 4.0 (2.3-5.2) .77 
Platelets (×103/μL) 392 (302-698) 455 (235-663) .91 

Results shown as median and interquartile range.

Mann-Whitney U test.

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