Main features, advantages, and disadvantages of18F-FDG–PET/CT and WB-DW-MRI in MM
| . | 18F-FDG–PET/CT . | WB-DW-MRI . |
|---|---|---|
| Scanning time | 15-20 minutes (60 minutes after radiotracer infusion) | 40-60 minutes |
| Radiation exposure | 10-25 mSv | None |
| Diffuse BM involvement | Lower sensitivity | Higher sensitivity |
| Detection of FLs | Lower sensitivity | Higher sensitivity |
| Detection of PSD | Lower sensitivity | Higher sensitivity |
| Detection of EMD | Gold-standard technique | Less explored role (apparent similar sensitivity) |
| Prognostic features | >3 FLs, high SUVmax, other quantitative parameters (MTV, TLG, IBI, and PBI) | DD, >3 large (>5 cm2) FLs, high TDV, high ADC values |
| Role in response assessment | Gold-standard technique (IMWG); recent IMPeTUs for definition of metabolic responses (prognostic role of DS <4) | Recommended technique for British guidelines (MY-RADS criteria: prognostic role of RAC1) |
| . | 18F-FDG–PET/CT . | WB-DW-MRI . |
|---|---|---|
| Scanning time | 15-20 minutes (60 minutes after radiotracer infusion) | 40-60 minutes |
| Radiation exposure | 10-25 mSv | None |
| Diffuse BM involvement | Lower sensitivity | Higher sensitivity |
| Detection of FLs | Lower sensitivity | Higher sensitivity |
| Detection of PSD | Lower sensitivity | Higher sensitivity |
| Detection of EMD | Gold-standard technique | Less explored role (apparent similar sensitivity) |
| Prognostic features | >3 FLs, high SUVmax, other quantitative parameters (MTV, TLG, IBI, and PBI) | DD, >3 large (>5 cm2) FLs, high TDV, high ADC values |
| Role in response assessment | Gold-standard technique (IMWG); recent IMPeTUs for definition of metabolic responses (prognostic role of DS <4) | Recommended technique for British guidelines (MY-RADS criteria: prognostic role of RAC1) |
IBI, intensity of bone involvement; PBI, percentage of bone involvement; TLG, total lesion glycolysis.