Adverse effects after treatment with CHOP and R-CHOP
. | CHOP, % . | . | . | . | R-CHOP, % . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adverse effect . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | ||||||
| Hemoglobin level | 29 | 20 | 9 | 1 | 31 | 19 | 8 | 1 | ||||||
| Leukocyte count | 10 | 18 | 38 | 23 | 9 | 15 | 43 | 26 | ||||||
| Granulocyte count | 10 | 10 | 23 | 30 | 7 | 12 | 22 | 41 | ||||||
| Platelet count | 11 | 5 | 5 | 3 | 9 | 8 | 4 | 2 | ||||||
| Bleeding | 2 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | ||||||
| Nausea/vomiting | 32 | 12 | 6 | 0 | 32 | 13 | 4 | 0 | ||||||
| Stomatitis | 23 | 6 | 2 | 0 | 18 | 8 | 1 | 0 | ||||||
| Obstipation | 10 | 3 | 1 | 0 | 9 | 6 | 2 | 0 | ||||||
| Diarrhea | 8 | 3 | 3 | 0 | 8 | 3 | 2 | 0 | ||||||
| Fever | 7 | 15 | 1 | 0 | 9 | 20 | 0 | 0 | ||||||
| Alopecia | 9 | 16 | 56 | 5 | 5 | 14 | 63 | 4 | ||||||
| Infection | 15 | 14 | 6 | 1 | 17 | 16 | 5 | 0 | ||||||
| Cardiac dysfunction | 2 | 2 | 1 | 0 | 2 | 1 | 2 | 1 | ||||||
| Cardiac arrhythmia | 2 | 2 | 0 | 0 | 5 | 1 | 1 | 1 | ||||||
| Neurotoxicity | 34 | 8 | 2 | 0 | 25 | 9 | 1 | 0 | ||||||
| CNS toxicity | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | ||||||
| Allergy | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 0 | ||||||
. | CHOP, % . | . | . | . | R-CHOP, % . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adverse effect . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | ||||||
| Hemoglobin level | 29 | 20 | 9 | 1 | 31 | 19 | 8 | 1 | ||||||
| Leukocyte count | 10 | 18 | 38 | 23 | 9 | 15 | 43 | 26 | ||||||
| Granulocyte count | 10 | 10 | 23 | 30 | 7 | 12 | 22 | 41 | ||||||
| Platelet count | 11 | 5 | 5 | 3 | 9 | 8 | 4 | 2 | ||||||
| Bleeding | 2 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | ||||||
| Nausea/vomiting | 32 | 12 | 6 | 0 | 32 | 13 | 4 | 0 | ||||||
| Stomatitis | 23 | 6 | 2 | 0 | 18 | 8 | 1 | 0 | ||||||
| Obstipation | 10 | 3 | 1 | 0 | 9 | 6 | 2 | 0 | ||||||
| Diarrhea | 8 | 3 | 3 | 0 | 8 | 3 | 2 | 0 | ||||||
| Fever | 7 | 15 | 1 | 0 | 9 | 20 | 0 | 0 | ||||||
| Alopecia | 9 | 16 | 56 | 5 | 5 | 14 | 63 | 4 | ||||||
| Infection | 15 | 14 | 6 | 1 | 17 | 16 | 5 | 0 | ||||||
| Cardiac dysfunction | 2 | 2 | 1 | 0 | 2 | 1 | 2 | 1 | ||||||
| Cardiac arrhythmia | 2 | 2 | 0 | 0 | 5 | 1 | 1 | 1 | ||||||
| Neurotoxicity | 34 | 8 | 2 | 0 | 25 | 9 | 1 | 0 | ||||||
| CNS toxicity | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | ||||||
| Allergy | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 0 | ||||||
Adverse effects were comparable between treatment arms with the exception of a higher frequency of severe granulocytopenia after treatment with R-CHOP (P = .01). This difference was of clinically minor relevance, however, because no increase in infectious complications was observed.