Patient characteristics according to the NPM1/FLT3 ITD mutation status
. | FLT3 ITD negative, n = 203 . | . | FLT3 ITD positive, n = 97 . | . | . | ||
|---|---|---|---|---|---|---|---|
| Characteristics . | NPM1 mutated, n = 86 . | NPM1 unmutated, n = 117 . | NPM1 mutated, n = 59 . | NPM1 unmutated, n = 38 . | P . | ||
| Sex, no. | .03 | ||||||
| Female | 51 | 57 | 42 | 19 | |||
| Male | 35 | 60 | 17 | 19 | |||
| Type AML, no. | .50 | ||||||
| De novo | 78 | 95 | 53 | 31 | |||
| s-AML | 3 | 11 | 2 | 2 | |||
| t-AML | 3 | 2 | 1 | 0 | |||
| Missing | 2 | 9 | 3 | 5 | |||
| Median age, y (range) | 49 (25-60) | 49 (16-60) | 47 (18-60) | 43 (19-60) | .55 | ||
| Median hemoglobin level, g/L (range) | 90 (52-149) | 96 (48-176) | 93 (58-140) | 85 (54-119) | .10 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median platelet count, × 109/L (range) | 68 (12-746) | 49 (8-435) | 61 (16-248) | 64 (12-249) | .03 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median WBC count, × 109/L (range) | 19.8 (0.2-328) | 9.69 (0.41-369) | 43.5 (0.7-345) | 12.4 (0.7-235) | < .001 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median PB blasts, % (range) | 40 (0-99) | 32 (0-98) | 50 (0-100) | 48 (0-96) | .05 | ||
| Missing, no. | 5 | 12 | 5 | 3 | |||
| Median BM blasts, % (range) | 80 (0-100) | 70 (0-98) | 85 (0-100) | 83.5 (0-95) | < .001 | ||
| Missing, no. | 8 | 13 | 8 | 4 | |||
| Median percentage of CD34+ cells (range) | 1 (0-90) | 37 (0-100) | 4.5 (0-50) | 48.5 (0-95) | < .001 | ||
| Missing, no. | 29 | 40 | 25 | 8 | |||
| Median LDH, U/L (range) | 461.5 (89-1825) | 313 (121-1620) | 704 (203-4091) | 472 (122-2992) | < .001 | ||
| Missing, no. | 6 | 8 | 5 | 6 | |||
| Lymphadenopathy, no. (%) | 20 (24) | 13 (12) | 14 (25) | 8 (24) | .07 | ||
| Missing, no. | 5 | 9 | 3 | 5 | |||
| Extramedullary involvement, no. (%) | 15 (18) | 8 (7) | 10 (18) | 2 (5) | .05 | ||
| Missing, no. | 3 | 8 | 3 | 4 | |||
| FAB subtype, no. | ND | ||||||
| M0 | 1 | 10 | 0 | 2 | |||
| M1 | 8 | 18 | 6 | 9 | |||
| M2 | 19 | 33 | 15 | 10 | |||
| M4 | 29 | 20 | 23 | 8 | |||
| M5 | 16 | 9 | 9 | 2 | |||
| M6 | 5 | 1 | 0 | 0 | |||
| Missing | 8 | 26 | 6 | 7 | |||
| Splenomegaly,*no. (%) | 37 (43) | 38 (34) | 18 (31) | 12 (34) | .48 | ||
| Missing, no. | 0 | 6 | 2 | 3 | |||
. | FLT3 ITD negative, n = 203 . | . | FLT3 ITD positive, n = 97 . | . | . | ||
|---|---|---|---|---|---|---|---|
| Characteristics . | NPM1 mutated, n = 86 . | NPM1 unmutated, n = 117 . | NPM1 mutated, n = 59 . | NPM1 unmutated, n = 38 . | P . | ||
| Sex, no. | .03 | ||||||
| Female | 51 | 57 | 42 | 19 | |||
| Male | 35 | 60 | 17 | 19 | |||
| Type AML, no. | .50 | ||||||
| De novo | 78 | 95 | 53 | 31 | |||
| s-AML | 3 | 11 | 2 | 2 | |||
| t-AML | 3 | 2 | 1 | 0 | |||
| Missing | 2 | 9 | 3 | 5 | |||
| Median age, y (range) | 49 (25-60) | 49 (16-60) | 47 (18-60) | 43 (19-60) | .55 | ||
| Median hemoglobin level, g/L (range) | 90 (52-149) | 96 (48-176) | 93 (58-140) | 85 (54-119) | .10 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median platelet count, × 109/L (range) | 68 (12-746) | 49 (8-435) | 61 (16-248) | 64 (12-249) | .03 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median WBC count, × 109/L (range) | 19.8 (0.2-328) | 9.69 (0.41-369) | 43.5 (0.7-345) | 12.4 (0.7-235) | < .001 | ||
| Missing, no. | 3 | 8 | 3 | 3 | |||
| Median PB blasts, % (range) | 40 (0-99) | 32 (0-98) | 50 (0-100) | 48 (0-96) | .05 | ||
| Missing, no. | 5 | 12 | 5 | 3 | |||
| Median BM blasts, % (range) | 80 (0-100) | 70 (0-98) | 85 (0-100) | 83.5 (0-95) | < .001 | ||
| Missing, no. | 8 | 13 | 8 | 4 | |||
| Median percentage of CD34+ cells (range) | 1 (0-90) | 37 (0-100) | 4.5 (0-50) | 48.5 (0-95) | < .001 | ||
| Missing, no. | 29 | 40 | 25 | 8 | |||
| Median LDH, U/L (range) | 461.5 (89-1825) | 313 (121-1620) | 704 (203-4091) | 472 (122-2992) | < .001 | ||
| Missing, no. | 6 | 8 | 5 | 6 | |||
| Lymphadenopathy, no. (%) | 20 (24) | 13 (12) | 14 (25) | 8 (24) | .07 | ||
| Missing, no. | 5 | 9 | 3 | 5 | |||
| Extramedullary involvement, no. (%) | 15 (18) | 8 (7) | 10 (18) | 2 (5) | .05 | ||
| Missing, no. | 3 | 8 | 3 | 4 | |||
| FAB subtype, no. | ND | ||||||
| M0 | 1 | 10 | 0 | 2 | |||
| M1 | 8 | 18 | 6 | 9 | |||
| M2 | 19 | 33 | 15 | 10 | |||
| M4 | 29 | 20 | 23 | 8 | |||
| M5 | 16 | 9 | 9 | 2 | |||
| M6 | 5 | 1 | 0 | 0 | |||
| Missing | 8 | 26 | 6 | 7 | |||
| Splenomegaly,*no. (%) | 37 (43) | 38 (34) | 18 (31) | 12 (34) | .48 | ||
| Missing, no. | 0 | 6 | 2 | 3 | |||
WBC indicates white blood cell; PB, peripheral blood; BM, bone marrow; LDH, lactate dehydrogenase, normal value less than 240 U/L; no., number; and ND, not determined.
Defined as more than 13 cm as measured by ultrasonography.