Pathologic features of aged Il12rb2 KO mice
. | . | Multiorgan lymphoid infiltrates . | . | . | Tumors . | . | |||
---|---|---|---|---|---|---|---|---|---|
Age, mo; n = 13 . | Immune-complex glomerulonephritis . | Kidney . | Liver . | Salivary glands . | Lymph-node plasmacytoma . | Lung carcinoma . | |||
15 | + | + | + | + | + | Not tested | |||
15 | + | + | + | - | - | Not tested | |||
16 | + | + | + | + | - | Not tested | |||
16 | + | + | + | - | - | Not tested | |||
17 | + | + | + | - | - | - | |||
18 | + | + | + | - | + | - | |||
18 | + | + | + | + | - | + | |||
21 | + | + | + | + | + | - | |||
21 | + | + | + | - | + | - | |||
22 | + | + | + | - | - | + | |||
24 | + | + | + | - | - | - | |||
24 | + | + | + | + | - | - | |||
26 | + | + | + | - | - | Not tested | |||
Affected mice, % | 13/13 = 100 | 13/13 = 100 | 13/13 = 100 | 5/13 = 40 | 4/13 = 31 | 2/8 = 25 |
. | . | Multiorgan lymphoid infiltrates . | . | . | Tumors . | . | |||
---|---|---|---|---|---|---|---|---|---|
Age, mo; n = 13 . | Immune-complex glomerulonephritis . | Kidney . | Liver . | Salivary glands . | Lymph-node plasmacytoma . | Lung carcinoma . | |||
15 | + | + | + | + | + | Not tested | |||
15 | + | + | + | - | - | Not tested | |||
16 | + | + | + | + | - | Not tested | |||
16 | + | + | + | - | - | Not tested | |||
17 | + | + | + | - | - | - | |||
18 | + | + | + | - | + | - | |||
18 | + | + | + | + | - | + | |||
21 | + | + | + | + | + | - | |||
21 | + | + | + | - | + | - | |||
22 | + | + | + | - | - | + | |||
24 | + | + | + | - | - | - | |||
24 | + | + | + | + | - | - | |||
26 | + | + | + | - | - | Not tested | |||
Affected mice, % | 13/13 = 100 | 13/13 = 100 | 13/13 = 100 | 5/13 = 40 | 4/13 = 31 | 2/8 = 25 |