Table 1.

Pathologic features of aged Il12rb2 KO mice




Multiorgan lymphoid infiltrates

Tumors
Age, mo; n = 13
Immune-complex glomerulonephritis
Kidney
Liver
Salivary glands
Lymph-node plasmacytoma
Lung carcinoma
15   +   +   +   +   +   Not tested  
15   +   +   +   -   -   Not tested  
16   +   +   +   +   -   Not tested  
16   +   +   +   -   -   Not tested  
17   +   +   +   -   -   -  
18   +   +   +   -   +   -  
18   +   +   +   +   -   +  
21   +   +   +   +   +   -  
21   +   +   +   -   +   -  
22   +   +   +   -   -   +  
24   +   +   +   -   -   -  
24   +   +   +   +   -   -  
26   +   +   +   -   -   Not tested  
Affected mice, %
 
13/13 = 100
 
13/13 = 100
 
13/13 = 100
 
5/13 = 40
 
4/13 = 31
 
2/8 = 25
 



Multiorgan lymphoid infiltrates

Tumors
Age, mo; n = 13
Immune-complex glomerulonephritis
Kidney
Liver
Salivary glands
Lymph-node plasmacytoma
Lung carcinoma
15   +   +   +   +   +   Not tested  
15   +   +   +   -   -   Not tested  
16   +   +   +   +   -   Not tested  
16   +   +   +   -   -   Not tested  
17   +   +   +   -   -   -  
18   +   +   +   -   +   -  
18   +   +   +   +   -   +  
21   +   +   +   +   +   -  
21   +   +   +   -   +   -  
22   +   +   +   -   -   +  
24   +   +   +   -   -   -  
24   +   +   +   +   -   -  
26   +   +   +   -   -   Not tested  
Affected mice, %
 
13/13 = 100
 
13/13 = 100
 
13/13 = 100
 
5/13 = 40
 
4/13 = 31
 
2/8 = 25
 
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