Major hematologic and nonhematologic toxicities
Toxicity . | Grade 1-2, % of patients . | Grade 3-4, % of patients . |
|---|---|---|
| Hematologic toxicity | ||
| Anemia | 6 | 6 |
| Neutropenia | 32 | 12 |
| Leukopenia | 15 | 9 |
| Lymphopenia | 15 | 6 |
| Thrombocytopenia | 27 | 0 |
| Nonhematologic toxicity | ||
| Fatigue | 41 | 15 |
| Muscle weakness | 29 | 6 |
| Pneumonitis | 3 | 6 |
| Skin rash | 6 | 6 |
| Anxiety | 15 | 6 |
| Agitation | 15 | 3 |
| Cardiac arrhythmia | 3 | 3 |
| Nausea | 3 | 3 |
| Hyperglycemia | 3 | 3 |
| Elevated AST level | 0 | 3 |
| Infection | 0 | 3 |
| Colonic perforation | 0 | 3 |
| Increased liver enzymes | 0 | 3 |
| Deep vein thrombosis/pulmonary embolism | 0 | 3 |
| Neuropathy | 21 | 0 |
| Constipation | 15 | 0 |
| Depression | 15 | 0 |
| Confusion | 12 | 0 |
| Dizziness | 9 | 0 |
| Dyspepsia | 9 | 0 |
| Elevated alkaline phosphatase level | 6 | 0 |
| Bilirubin level | 6 | 0 |
| Diarrhea | 6 | 0 |
| Stomatitis | 6 | 0 |
Toxicity . | Grade 1-2, % of patients . | Grade 3-4, % of patients . |
|---|---|---|
| Hematologic toxicity | ||
| Anemia | 6 | 6 |
| Neutropenia | 32 | 12 |
| Leukopenia | 15 | 9 |
| Lymphopenia | 15 | 6 |
| Thrombocytopenia | 27 | 0 |
| Nonhematologic toxicity | ||
| Fatigue | 41 | 15 |
| Muscle weakness | 29 | 6 |
| Pneumonitis | 3 | 6 |
| Skin rash | 6 | 6 |
| Anxiety | 15 | 6 |
| Agitation | 15 | 3 |
| Cardiac arrhythmia | 3 | 3 |
| Nausea | 3 | 3 |
| Hyperglycemia | 3 | 3 |
| Elevated AST level | 0 | 3 |
| Infection | 0 | 3 |
| Colonic perforation | 0 | 3 |
| Increased liver enzymes | 0 | 3 |
| Deep vein thrombosis/pulmonary embolism | 0 | 3 |
| Neuropathy | 21 | 0 |
| Constipation | 15 | 0 |
| Depression | 15 | 0 |
| Confusion | 12 | 0 |
| Dizziness | 9 | 0 |
| Dyspepsia | 9 | 0 |
| Elevated alkaline phosphatase level | 6 | 0 |
| Bilirubin level | 6 | 0 |
| Diarrhea | 6 | 0 |
| Stomatitis | 6 | 0 |
AST indicates aspartate amino transferase.