Engraftment of CD13+/- CD123+/- fractions of cord blood Lin-CD34+CD38- cells in NOD/SCID-β2m-/- mice and SRC frequency within these fractions
. | No. mice engrafted/no. mice injected . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Cell dose/mouse . | CD13+CD123+* . | CD13+CD123-† . | CD13-CD123+‡ . | CD13-CD123-§ . | |||
| Mice killed at 6 wk | |||||||
| 625 | 3/3 | 1/4 | ND | ND | |||
| 1000-2500 | 6/7 | 4/7 | 5/6 | 4/10 | |||
| More than 6000 | 8/8 | 5/5 | ND | ND | |||
| Mice killed at 12 wk | |||||||
| 1000-1300 | 2/3 | ND | ND | 1/1 | |||
| More than 1700 | ND | 2/2 | 2/2 | 2/2 | |||
. | No. mice engrafted/no. mice injected . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Cell dose/mouse . | CD13+CD123+* . | CD13+CD123-† . | CD13-CD123+‡ . | CD13-CD123-§ . | |||
| Mice killed at 6 wk | |||||||
| 625 | 3/3 | 1/4 | ND | ND | |||
| 1000-2500 | 6/7 | 4/7 | 5/6 | 4/10 | |||
| More than 6000 | 8/8 | 5/5 | ND | ND | |||
| Mice killed at 12 wk | |||||||
| 1000-1300 | 2/3 | ND | ND | 1/1 | |||
| More than 1700 | ND | 2/2 | 2/2 | 2/2 | |||
ND indicates not determined; CI, confidence interval.
SRC frequency: 1 in 575 cells; 95% CI, 1 in 1293 to 1 in 256 cells
SRC frequency: 1 in 1803 cells; 95% CI, 1 in 2604 to 1 in 1249 cells
SRC frequency: 1 in 1157 cells; 95% CI, 1 in 3205 to 1 in 417 cells
SRC frequency: 1 in 4383 cells; 95% CI, 1 in 11 880 to 1 in 1617 cells