Table 2. Frequency of Mk and number of... | American Society of Hematology

Table 2.

Frequency of Mk and number of fibers in femur and spleen from 12- to 13-month-old mice harboring the GATA-1^low mutation in the C57BL/6, DBA/2, and CD1 backgrounds, as indicated

		Femur			Spleen
Strain	Genotype	Mk/mm²	Fibers/mm²	Mk/mm²	Fibers/mm²	Mk/mm²	Fibers/mm²
C57BL/6
F1 + F2	Wild type	110 ± 10	1372 ± 647	20 ± 18	421 ± 233	BD	333 ± 41
F1 + F2	Gata 1^low/+	66 ± 9^*	2897 ± 541^*	109 ± 2^*	2269 ± 300^*	0.1 ± 0.2	359 ± 35
DBA/2
F1 + F2	Wild type	65	1254	25	972	BD	844
F1 + F2	Gata 1^low/+	80 ± 24	2797 ± 1712	70 ± 10^*	1663 ± 355	BD	423 ± 111
F2	Gata 1^low/0	56 ± 5	3124 ± 1216^*	130 ± 47^*	2521 ± 216^*	1.5 ± 0.7^*	1229 ± 348^*
CD1
F1 + F2	Wild type	122 ± 33	1080 ± 400	32 ± 12	380 ± 145	BD	290 ± 120
F1 + F2	Gata 1^low/+	63 ± 33	1867 ± 1012	84 ± 30^*	1871 ± 189^*	4 ± 2^*	608 ± 312
F2	Gata 1^low/0	340 ± 125^*	3970 ± 890^*	366 ± 110^*	2540 ± 755^*	13 ± 4^*	1870 ± 700^*

		Femur			Spleen
Strain	Genotype	Mk/mm²	Fibers/mm²	Mk/mm²	Fibers/mm²	Mk/mm²	Fibers/mm²
C57BL/6
F1 + F2	Wild type	110 ± 10	1372 ± 647	20 ± 18	421 ± 233	BD	333 ± 41
F1 + F2	Gata 1^low/+	66 ± 9^*	2897 ± 541^*	109 ± 2^*	2269 ± 300^*	0.1 ± 0.2	359 ± 35
DBA/2
F1 + F2	Wild type	65	1254	25	972	BD	844
F1 + F2	Gata 1^low/+	80 ± 24	2797 ± 1712	70 ± 10^*	1663 ± 355	BD	423 ± 111
F2	Gata 1^low/0	56 ± 5	3124 ± 1216^*	130 ± 47^*	2521 ± 216^*	1.5 ± 0.7^*	1229 ± 348^*
CD1
F1 + F2	Wild type	122 ± 33	1080 ± 400	32 ± 12	380 ± 145	BD	290 ± 120
F1 + F2	Gata 1^low/+	63 ± 33	1867 ± 1012	84 ± 30^*	1871 ± 189^*	4 ± 2^*	608 ± 312
F2	Gata 1^low/0	340 ± 125^*	3970 ± 890^*	366 ± 110^*	2540 ± 755^*	13 ± 4^*	1870 ± 700^*

The values obtained in age-matched littermates are reported for comparison.

BD indicates below detection.

Values statistically different (P < .01) from those observed in the corresponding wild-type littermates

View Large

This Feature Is Available To Subscribers Only