Frequency as a percentage of CD117+/Scal+, CD117+/CD34+, and TER-119+/CD71+ cells in the tissues from 16- to 20-month-old mice harboring the Gata1low mutation in the C57BL/6, DBA/2, and CD1 backgrounds, as indicated
. | . | Bone marrow . | . | . | Spleen . | . | . | Liver . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain . | Genotype . | CD117+/Scal+ . | CD117+/CD34+ . | TER119+/CD71+ . | CD117+/Scal+ . | CD117+/CD34+ . | TER119+/CD71+ . | CD117+/CD34+ . | TER119+/CD71+ . | |||||
| C57BL/6 | ||||||||||||||
| F1 + F2 | Wild type | 1.9 ± 0.1 | 5.3 ± 12 | 17.9 ± 1.5 | 2.5 ± 1.4 | 1.0* | 8.0 ± 0.1 | BD | 1.6 ± 1.7 | |||||
| F1 + F2 | Gata 1low/+ | 1.5 ± 0.4 | 4.0 ± 2.2 | 22.6 ± 10.9 | 1.4 ± 0.8 | 1.4 ± 1.3 | 6.6 ± 3.7 | BD | 6.1 ± 3.2 | |||||
| DBA/2 | ||||||||||||||
| F1 + F2 | Wild type | 1.2 ± 0.1 | 4.5 ± 1.8 | 26 ± 3 | 1.4 ± 0.4 | 3.1 ± 0.8 | 6.6 ± 3.4 | BD | 5.6 ± 1.3 | |||||
| F1 + F2 | Gata 1low/+ | 0.8 ± 0.3 | 6.0 ± 3.4 | 26 ± 19 | 2.8 ± 2.4 | 5.9 ± 1.4 | 29 ± 19 | BD | 14.8 ± 9.6 | |||||
| F2 | Gata 1low/0 | 1.5 ± 0.4 | 4.7 ± 0.5 | 19.1 ± 3.0† | 9.5 ± 0.5† | 11.2 ± 4.0† | 8.9 ± 1.0 | BD | 3.4 ± 1.2 | |||||
| CD1 | ||||||||||||||
| F1 + F2 | Wild type | 3.4 ± 0.5 | 5.8 ± 0.6 | 30.0 ± 5.5 | 2.2 ± 0.5 | 1.6 ± 0.5 | 5.0 ± 1.3 | BD | 5.8 ± 0.9 | |||||
| F1 + F2 | Gata 1low/+ | ND | ND | ND | 2.7 ± 0.6 | 3.7 ± 2.2 | 27.8 ± 8.3 | ND | ND | |||||
| F2 | Gata 1low/0 | 0.9 ± 0.1† | 4.0 ± 0.8† | 28.2 ± 4.7 | 1.0 ± 0.2† | 7.3 ± 0.9† | 31.2 ± 10.6† | 2.7 ± 0.4† | 13.7 ± 4.7† | |||||
. | . | Bone marrow . | . | . | Spleen . | . | . | Liver . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain . | Genotype . | CD117+/Scal+ . | CD117+/CD34+ . | TER119+/CD71+ . | CD117+/Scal+ . | CD117+/CD34+ . | TER119+/CD71+ . | CD117+/CD34+ . | TER119+/CD71+ . | |||||
| C57BL/6 | ||||||||||||||
| F1 + F2 | Wild type | 1.9 ± 0.1 | 5.3 ± 12 | 17.9 ± 1.5 | 2.5 ± 1.4 | 1.0* | 8.0 ± 0.1 | BD | 1.6 ± 1.7 | |||||
| F1 + F2 | Gata 1low/+ | 1.5 ± 0.4 | 4.0 ± 2.2 | 22.6 ± 10.9 | 1.4 ± 0.8 | 1.4 ± 1.3 | 6.6 ± 3.7 | BD | 6.1 ± 3.2 | |||||
| DBA/2 | ||||||||||||||
| F1 + F2 | Wild type | 1.2 ± 0.1 | 4.5 ± 1.8 | 26 ± 3 | 1.4 ± 0.4 | 3.1 ± 0.8 | 6.6 ± 3.4 | BD | 5.6 ± 1.3 | |||||
| F1 + F2 | Gata 1low/+ | 0.8 ± 0.3 | 6.0 ± 3.4 | 26 ± 19 | 2.8 ± 2.4 | 5.9 ± 1.4 | 29 ± 19 | BD | 14.8 ± 9.6 | |||||
| F2 | Gata 1low/0 | 1.5 ± 0.4 | 4.7 ± 0.5 | 19.1 ± 3.0† | 9.5 ± 0.5† | 11.2 ± 4.0† | 8.9 ± 1.0 | BD | 3.4 ± 1.2 | |||||
| CD1 | ||||||||||||||
| F1 + F2 | Wild type | 3.4 ± 0.5 | 5.8 ± 0.6 | 30.0 ± 5.5 | 2.2 ± 0.5 | 1.6 ± 0.5 | 5.0 ± 1.3 | BD | 5.8 ± 0.9 | |||||
| F1 + F2 | Gata 1low/+ | ND | ND | ND | 2.7 ± 0.6 | 3.7 ± 2.2 | 27.8 ± 8.3 | ND | ND | |||||
| F2 | Gata 1low/0 | 0.9 ± 0.1† | 4.0 ± 0.8† | 28.2 ± 4.7 | 1.0 ± 0.2† | 7.3 ± 0.9† | 31.2 ± 10.6† | 2.7 ± 0.4† | 13.7 ± 4.7† | |||||
The values obtained in age-matched normal littermates are reported for comparison. Data represent the means (±SD) of results obtained on at least 3 to 4 mice per experimental group.
BD indicates below detection; ND, not done.
Only one data point was available
Values statistically different (P < .05) from those obtained in the corresponding wild-type controls