Summary of the phenotypic trait expressed by GATA-1low mutants in different backgrounds
. | C57BL/6* . | CD1 . | DBA/2 . | Putative gene modifier . |
|---|---|---|---|---|
| Neonates | ||||
| Mortality | High | Intermediate | Low | Fv2 |
| Anemia | Yes | Yes | Yes | None |
| Thrombocytopenia | Yes | Yes | Yes | None |
| Adults | ||||
| Occurrence of anemia | No | 15-20 months | 12-13 months | Fv2 |
| Splenic hemopoiesis | Yes | Yes | Limited | Fv2 |
| Tear-drop poikilocytes | 12 months | 15 months | None | ? |
| Marrow fibrosis | Yes | Yes | Limited | None |
| Osteosclerosis | Yes | Limited | No | ? (osteoclast activity) |
| Stem/progenitor cell trafficking | No | Yes | No | bFGF signaling STAT-5a,b |
| Extramedullary hemopoiesis | No | Yes | No | bFGF signaling STAT-5a,b |
. | C57BL/6* . | CD1 . | DBA/2 . | Putative gene modifier . |
|---|---|---|---|---|
| Neonates | ||||
| Mortality | High | Intermediate | Low | Fv2 |
| Anemia | Yes | Yes | Yes | None |
| Thrombocytopenia | Yes | Yes | Yes | None |
| Adults | ||||
| Occurrence of anemia | No | 15-20 months | 12-13 months | Fv2 |
| Splenic hemopoiesis | Yes | Yes | Limited | Fv2 |
| Tear-drop poikilocytes | 12 months | 15 months | None | ? |
| Marrow fibrosis | Yes | Yes | Limited | None |
| Osteosclerosis | Yes | Limited | No | ? (osteoclast activity) |
| Stem/progenitor cell trafficking | No | Yes | No | bFGF signaling STAT-5a,b |
| Extramedullary hemopoiesis | No | Yes | No | bFGF signaling STAT-5a,b |
Because of the embryonic lethality (Figure 1), only data on heterozygous F1 + F2 females are available