Comparison of immunohistochemical findings in pediatric and adult DLBCL
. | Pediatric DLBCL, no. (%) . | Adult DLBCL, no. (%) . | . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | . | Hans et al15 . | Chang et al24 . | Colomo et al25 . | Klapper et al . | Total adult DLBCL . | P . | ||||
| CD10 | 39 of 57 (68) | 42 of 152 (28) | 16 of 42 (38) | 27 of 128 (21) | 76 of 207 (37) | 161 of 529 (30) | < .001 | ||||
| BCL2 | 22 of 55 (40) | 76 of 152 (50) | ND | 74 of 126 (59) | 137 of 199 (69) | 287 of 477 (60) | NS | ||||
| BCL6 | 47 of 52 (90) | 85 of 152 (56) | 21 of 41 (51) | 91 of 127 (72) | 188 of 221 (85) | 385 of 541 (71) | .002 | ||||
| Mum-1 | 21 of 35 (60) | 71 of 152 (47) | 22 of 42 (52) | 68 of 128 (53) | 146 of 210 (70) | 307 of 532 (58) | NS | ||||
| GCB | 43 of 52 (83) | 64 of 152 (42) | 15 of 38 (40) | 57 of 119 (48) | 97 of 207 (47) | 233 of 516 (45) | < .001 | ||||
. | Pediatric DLBCL, no. (%) . | Adult DLBCL, no. (%) . | . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | . | Hans et al15 . | Chang et al24 . | Colomo et al25 . | Klapper et al . | Total adult DLBCL . | P . | ||||
| CD10 | 39 of 57 (68) | 42 of 152 (28) | 16 of 42 (38) | 27 of 128 (21) | 76 of 207 (37) | 161 of 529 (30) | < .001 | ||||
| BCL2 | 22 of 55 (40) | 76 of 152 (50) | ND | 74 of 126 (59) | 137 of 199 (69) | 287 of 477 (60) | NS | ||||
| BCL6 | 47 of 52 (90) | 85 of 152 (56) | 21 of 41 (51) | 91 of 127 (72) | 188 of 221 (85) | 385 of 541 (71) | .002 | ||||
| Mum-1 | 21 of 35 (60) | 71 of 152 (47) | 22 of 42 (52) | 68 of 128 (53) | 146 of 210 (70) | 307 of 532 (58) | NS | ||||
| GCB | 43 of 52 (83) | 64 of 152 (42) | 15 of 38 (40) | 57 of 119 (48) | 97 of 207 (47) | 233 of 516 (45) | < .001 | ||||
The immunohistochemical results are shown in number of positive cases of evaluable cases (percentage of positive cases). The data presented in this study on pediatric DLBCL are compared to data on adult DLBCL combined from published studies by Hans et al,15 Chang et al,24 and Colomo et al,25 as well as an unpublished study from our own group (W.K., R.S., unpublished observations, August 2005) by the χ2 test.
ND indicates not done; NS, not significant.