Severe nonhematologic toxicities in the IFM 95-01 trial analyzed by treatment allocation
Toxicity . | Total, no. (%) . | MP, no. . | M-DEX, no. . | DEX, no. . | DEX-IFN, no. . |
|---|---|---|---|---|---|
| Severe pyogenic infections | 59 (12) | 12 | 22 | 14 | 11 |
| Pulmonary | 25 (5) | 5 | 11 | 5 | 4 |
| Septicemia | 18 (4) | 2 | 5 | 6 | 5 |
| Other | 16 (3) | 5 | 6 | 3 | 2 |
| Severe hemorrhage | 10 (2) | 2 | 3 | 5 | 0 |
| Perforated diverticulum | 8 (2) | 0 | 3 | 1 | 4 |
| Psychiatric complications | 13 (2.5) | 0 | 2 | 3 | 8* |
| Severe diabetes | 16 (3) | 2 | 2 | 8 | 4 |
| DVT/pulmonary embolism | 21 (4) | 5 | 6 | 6 | 4 |
| Any severe toxicity | 121 (25) | 20 | 36 | 34 | 31 |
Toxicity . | Total, no. (%) . | MP, no. . | M-DEX, no. . | DEX, no. . | DEX-IFN, no. . |
|---|---|---|---|---|---|
| Severe pyogenic infections | 59 (12) | 12 | 22 | 14 | 11 |
| Pulmonary | 25 (5) | 5 | 11 | 5 | 4 |
| Septicemia | 18 (4) | 2 | 5 | 6 | 5 |
| Other | 16 (3) | 5 | 6 | 3 | 2 |
| Severe hemorrhage | 10 (2) | 2 | 3 | 5 | 0 |
| Perforated diverticulum | 8 (2) | 0 | 3 | 1 | 4 |
| Psychiatric complications | 13 (2.5) | 0 | 2 | 3 | 8* |
| Severe diabetes | 16 (3) | 2 | 2 | 8 | 4 |
| DVT/pulmonary embolism | 21 (4) | 5 | 6 | 6 | 4 |
| Any severe toxicity | 121 (25) | 20 | 36 | 34 | 31 |
The data were collected for 488 patients; for MP, n = 122; for M-DEX, n = 118; for DEX, n = 127; for DEX-IFN, n = 121.
DVT indicates deep venous thrombosis.
Including suicide in 1 patient