Solvent exposure among 541 cases of aplastic anemia and 2261 controls
. | Cases . | . | Controls . | . | Relative risk estimate† . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Solvent* . | No. . | % . | No. . | % . | Crude . | Multivariate‡(95% CI) . | |||
| Benzene | 7 | 1 | 8 | 0.3 | 3.7 | 3.5 (1.2-10) | |||
| At least 4 days' total exposure | 5 | 1 | 7 | 0.3 | 3.0 | 3.2 (1.0-11) | |||
| Fuels§ | 11 | 2 | 49 | 2 | 0.9 | 1.0 (0.5-2.0) | |||
| At least 4 days' total exposure | 9 | 2 | 47 | 2 | 0.8 | 0.8 (0.4-1.8) | |||
| Glues∥ | 39 | 7 | 128 | 6 | 1.3 | 1.2 (0.7-1.8) | |||
| At least 4 days' total exposure | 23 | 4 | 83 | 4 | 1.2 | 1.0 (0.6-1.7) | |||
| Other solvents¶ | 58 | 11 | 140 | 6 | 1.8 | 2.0 (1.4-2.8) | |||
| At least 4 days' total exposure | 40 | 7 | 106 | 5 | 1.7 | 1.9 (1.2-2.8) | |||
. | Cases . | . | Controls . | . | Relative risk estimate† . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Solvent* . | No. . | % . | No. . | % . | Crude . | Multivariate‡(95% CI) . | |||
| Benzene | 7 | 1 | 8 | 0.3 | 3.7 | 3.5 (1.2-10) | |||
| At least 4 days' total exposure | 5 | 1 | 7 | 0.3 | 3.0 | 3.2 (1.0-11) | |||
| Fuels§ | 11 | 2 | 49 | 2 | 0.9 | 1.0 (0.5-2.0) | |||
| At least 4 days' total exposure | 9 | 2 | 47 | 2 | 0.8 | 0.8 (0.4-1.8) | |||
| Glues∥ | 39 | 7 | 128 | 6 | 1.3 | 1.2 (0.7-1.8) | |||
| At least 4 days' total exposure | 23 | 4 | 83 | 4 | 1.2 | 1.0 (0.6-1.7) | |||
| Other solvents¶ | 58 | 11 | 140 | 6 | 1.8 | 2.0 (1.4-2.8) | |||
| At least 4 days' total exposure | 40 | 7 | 106 | 5 | 1.7 | 1.9 (1.2-2.8) | |||
Use in the year before admission. Categories not mutually exclusive
Relative to nonexposure to the solvent under consideration
The following factors were included in the model: age, sex, region, year of interview, solvent exposure, pesticide use, drug use. Statistically significant estimates are italicized
Kerosene (7 cases, 23 controls), gasoline (5 cases, 24 controls), fuel oil (1, 2), diesel fuel (0, 4)
Tra chang glue (22 cases, 75 controls), rubber glue (3, 15), leather shoe glue (1, 6), PVC blue (0, 7), polyvinyl acetate (0, 2), epoxy (0, 2), unspecified glue (13, 26). Type of glue was not recorded in phase 1; identified nonsolvent-based glues were not included in the phase 2 portion of the data. A total of 33 cases and 123 controls were exposed to solvent-based glues in phase 2 (crude relative risk estimate, 1.2)
Turpentine (12 cases, 24 controls: reported in phase 2 only), naphtha (2, 0), paint remover (1, 0), 3A thinner (0, 6), alcohol (1, 7), toluene (1, 1), methylethylketone (1, 0), dry-cleaning solvent (0, 2), unspecified thinner (43, 111), unspecified solvent (5, 12)