Drug exposure in days 29 to 180 among 541 cases of aplastic anemia and 2261 controls
. | Cases . | . | Controls . | . | Relative risk estimate* . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Drug . | No. . | % . | No. . | % . | Crude . | Multivariate†(95% CI) . | Original relative risk estimate‡ . | |||
| Chloramphenicol | 4 | 0.7 | 8 | 0.4 | 2.1 | 1.8 (0.5-6.5) | 2.7 (0.7-10) | |||
| Sulfonamides | 5 | 1 | 4 | 0.2 | 5.3 | 5.6 (1.4-22) | 7.9¶ | |||
| Tetracyclines | 10 | 2 | 23 | 1 | 1.8 | 1.6 (0.7-3.4) | 1.8 (0.6-5.6) | |||
| Mebendazole | 8 | 1 | 10 | 0.4 | 3.4 | 3.0 (1.2-7.8) | 6.3¶ | |||
| Thiazide diuretics | 10 | 2 | 11 | 0.5 | 3.9 | 3.8 (1.6-9.4) | 7.7 (1.5-40) | |||
| NSAIDs | 9 | 2 | 20 | 1 | 1.9 | 1.6 (0.7-3.8) | Not reported | |||
. | Cases . | . | Controls . | . | Relative risk estimate* . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Drug . | No. . | % . | No. . | % . | Crude . | Multivariate†(95% CI) . | Original relative risk estimate‡ . | |||
| Chloramphenicol | 4 | 0.7 | 8 | 0.4 | 2.1 | 1.8 (0.5-6.5) | 2.7 (0.7-10) | |||
| Sulfonamides | 5 | 1 | 4 | 0.2 | 5.3 | 5.6 (1.4-22) | 7.9¶ | |||
| Tetracyclines | 10 | 2 | 23 | 1 | 1.8 | 1.6 (0.7-3.4) | 1.8 (0.6-5.6) | |||
| Mebendazole | 8 | 1 | 10 | 0.4 | 3.4 | 3.0 (1.2-7.8) | 6.3¶ | |||
| Thiazide diuretics | 10 | 2 | 11 | 0.5 | 3.9 | 3.8 (1.6-9.4) | 7.7 (1.5-40) | |||
| NSAIDs | 9 | 2 | 20 | 1 | 1.9 | 1.6 (0.7-3.8) | Not reported | |||
Relative to nonexposure to the drug under consideration
The following factors were included in the model: age, sex, region, year of interview, solvent exposure, pesticide use, drug use. Statistically significant estimates are italicized
“Original relative risk estimates” are taken from the previously published findings of phase 142
Crude estimate with P < .05; the confidence interval was not provided