Alignment of inhibitory and noninhibitory chemokines identifies an N/QF motif specific to the inhibitory chemokines
Chemokine . | 310 helical turn sequence . |
|---|---|
| Human MIP-1α | IPQNFI |
| Murine MIP-1α | IPRQFI |
| Human MIP-1β | LPRNFV |
| Murine MIP-1β | LHRSFT |
| Human RANTES | LPRAHI |
| Murine RANTES | LPRAHV |
| Human MCP1 | ISVQRL |
Chemokine . | 310 helical turn sequence . |
|---|---|
| Human MIP-1α | IPQNFI |
| Murine MIP-1α | IPRQFI |
| Human MIP-1β | LPRNFV |
| Murine MIP-1β | LHRSFT |
| Human RANTES | LPRAHI |
| Murine RANTES | LPRAHV |
| Human MCP1 | ISVQRL |
Note that human and murine MIP-1α and human MIP-1β are active as HSPC inhibitors, whereas murine MIP-1β, human and murine RANTES, and human MCP1 are inactive.