Numbers and genotypic frequencies of protein S–K196E mutation in the DVT and control groups
Genotypes . | General population, no. (%) . | DVT group, no. (%) . |
|---|---|---|
| Additive model* | ||
| KK | 3585 (98.2) | 146 (90.7) |
| KE | 66 (1.8) | 13 (8.1) |
| EE | 0 (0.0) | 2 (1.2) |
| Total | 3651 (100.0) | 161 (100.0) |
| Dominant model† | ||
| KK | 3585 (98.2) | 146 (90.7) |
| KE + EE | 66 (1.8) | 15 (9.3) |
| Total | 3651 (100.0) | 161 (100.0) |
Genotypes . | General population, no. (%) . | DVT group, no. (%) . |
|---|---|---|
| Additive model* | ||
| KK | 3585 (98.2) | 146 (90.7) |
| KE | 66 (1.8) | 13 (8.1) |
| EE | 0 (0.0) | 2 (1.2) |
| Total | 3651 (100.0) | 161 (100.0) |
| Dominant model† | ||
| KK | 3585 (98.2) | 146 (90.7) |
| KE + EE | 66 (1.8) | 15 (9.3) |
| Total | 3651 (100.0) | 161 (100.0) |
DNA genotyping was performed by the TaqMan allele discrimination method.9 We have adopted the numbering standards of the Nomenclature Working Group, wherein the A of the ATG of the initiator Met codon is denoted as nucleotide + 1, and the initial Met residue is denoted as amino acid + 1, resulting in the renaming of several mutant alleles.10 Comparisons between the DVT cases and the controls were analyzed using a χ2 test with the genotypes as independent variables (indicated by P and OR) or using multiple logistic analyses with the genotypes as independent variables and age and sex as covariates (indicated by P′ and OR′).
For comparison of general population to DVT group, P was not determined
For comparison of general population to DVT group, P < .001; OR = 5.58 (3.11-10.01); P′ < .001; OR′ = 4.72 (2.39-9.31)