Table 3. Biological systems: additional... | American Society of Hematology

Table 3.

Biological systems: additional systems

System	File name prefix	Sample ID	Exposure
Healthy PBLs	HD-	STS-1, RPK-2	In vivo
Sensitive primary cells	IV-	BCP-ALL-40	Ex vivo
Sensitive cell lines^*	S-line-	C7H2, Pre B 697	In vitro
Resistant cell lines†	R-line-	C7R1, CEM-C1, Pre B-R4G4, C7R1^-dim-high	In vitro
Converted cell lines‡	C-line-	C7R1^-dim-low, CEM-C1^ratGR	In vitro
Cycloheximide sensitivity	CHX-	CEM-C7H2	In vitro
Mouse thymocytes	Mouse-	CD1	In vivo
Mouse thymocytes	Mouse-	CD1	Ex vivo

System	File name prefix	Sample ID	Exposure
Healthy PBLs	HD-	STS-1, RPK-2	In vivo
Sensitive primary cells	IV-	BCP-ALL-40	Ex vivo
Sensitive cell lines^*	S-line-	C7H2, Pre B 697	In vitro
Resistant cell lines†	R-line-	C7R1, CEM-C1, Pre B-R4G4, C7R1^-dim-high	In vitro
Converted cell lines‡	C-line-	C7R1^-dim-low, CEM-C1^ratGR	In vitro
Cycloheximide sensitivity	CHX-	CEM-C7H2	In vitro
Mouse thymocytes	Mouse-	CD1	In vivo
Mouse thymocytes	Mouse-	CD1	Ex vivo

The GC-sensitive human ALL cell lines CCRF-CEM-C7H2²⁸ and PreB-697²⁹

†

GC-resistant cell lines CEM-C7R1³¹ and CEM-C1^30,34 have been published

‡

“Converted” refers to cell lines in which GC sensitivity was restored either by stable transfection with wild-type rat GR (CEM-C1^ratGR) or by high-level expression of human GR carrying the GR^dim mutation³⁵ stably transfected into C7R1 (C7R1^dim-high). C7R1^dim-low expressed less GR^dim and remained GC-resistant (Figure S1)

View Large

This Feature Is Available To Subscribers Only