Regulation of top candidate genes derived from experimental systems
. | T-ALL (3) . | . | . | BCP-ALL (10) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol . | Up . | Down . | Both . | Up . | Down . | Both . | ||||
| LDH A | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| GPR65 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| MAP2K3 | 0 | 0 | 0 | 1 | 0 | 0 | ||||
| GZMA | 0 | 1 | 0 | 1 | 2 | 1 | ||||
| MYC | 1 | 0 | 0 | 1 | 3 | 0 | ||||
| NR3C1 | 3 | 0 | 0 | 2 | 0 | 0 | ||||
| BCL2L11 | 2 | 0 | 0 | 4 | 0 | 0 | ||||
. | T-ALL (3) . | . | . | BCP-ALL (10) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol . | Up . | Down . | Both . | Up . | Down . | Both . | ||||
| LDH A | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| GPR65 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| MAP2K3 | 0 | 0 | 0 | 1 | 0 | 0 | ||||
| GZMA | 0 | 1 | 0 | 1 | 2 | 1 | ||||
| MYC | 1 | 0 | 0 | 1 | 3 | 0 | ||||
| NR3C1 | 3 | 0 | 0 | 2 | 0 | 0 | ||||
| BCL2L11 | 2 | 0 | 0 | 4 | 0 | 0 | ||||
The data summarize the number of children where the indicated gene was found to be up-regulated (Up), down-regulated (Down), or regulated in different direction at the two time points investigated (Both). In all instances the cut-off was an M value of 1 or more or –1 or less. The complete data set for these and additional 26 genes found to be frequently regulated in experimental systems4 is shown in Table S1.