Summary of the effects of neutralizing antibodies against various adhesion molecules and chemokines on the adhesion of neutrophils, PBLs, and monocytes and their subsequent transendothelial and subendothelial migration patterns under disturbed flow
. | ICAM-1 . | VCAM-1 . | E-selectin . | MCP-1 . | IL-8 . | RANTES . | GRO-α . | IP-10 . | I-TAC . | SDF-1 . |
|---|---|---|---|---|---|---|---|---|---|---|
| Neutrophil | ||||||||||
| Adhesion | + | – | + | – | + | – | + | – | – | – |
| Transendothelial migration | + | – | + | – | + | – | + | – | – | – |
| Subendothelial migration | + | – | – | – | – | – | – | – | – | – |
| PBL | ||||||||||
| Adhesion | + | + | – | + | – | + | + | + | + | + |
| Transendothelial migration | + | + | – | + | – | + | + | – | + | + |
| Subendothelial migration | – | + | – | – | – | – | – | – | – | – |
| Monocyte | ||||||||||
| Adhesion | + | + | + | + | + | + | + | + | – | + |
| Transendothelial migration | + | + | + | + | – | + | + | + | – | + |
| Subendothelial migration | – | – | – | – | – | – | – | – | – | – |
. | ICAM-1 . | VCAM-1 . | E-selectin . | MCP-1 . | IL-8 . | RANTES . | GRO-α . | IP-10 . | I-TAC . | SDF-1 . |
|---|---|---|---|---|---|---|---|---|---|---|
| Neutrophil | ||||||||||
| Adhesion | + | – | + | – | + | – | + | – | – | – |
| Transendothelial migration | + | – | + | – | + | – | + | – | – | – |
| Subendothelial migration | + | – | – | – | – | – | – | – | – | – |
| PBL | ||||||||||
| Adhesion | + | + | – | + | – | + | + | + | + | + |
| Transendothelial migration | + | + | – | + | – | + | + | – | + | + |
| Subendothelial migration | – | + | – | – | – | – | – | – | – | – |
| Monocyte | ||||||||||
| Adhesion | + | + | + | + | + | + | + | + | – | + |
| Transendothelial migration | + | + | + | + | – | + | + | + | – | + |
| Subendothelial migration | – | – | – | – | – | – | – | – | – | – |
+ for adhesion indicates the neutralizing antibody has a significant effect on the number of adherent WBCs on EC/SMC; + for transendothelial migration, the neutralizing antibody has a significant effect on either the number of transmigrated WBCs or the transmigration time of WBCs; + for subendothelial migration, the neutralizing antibody has a significant effect on the total distance, the net distance, or the randomness of the subendothelial movement of transmigrated WBCs; – for the neutralizing antibody, no significant effect on the indicated behaviors of WBCs.