Table 3.

Cytogenetic results




Younger than 56 y

56-65 y

66-75 y

Older than 75 y

P*
No. patients   323   183   199   54   
Cytogenetic risk group, no. (%)      < .001 
    Favorable   51 (16)   10 (5)   10 (5)   2 (4)   
    Intermediate   149 (46)   101 (55)   110 (55)   24 (44)   
    Unfavorable   108 (33)   70 (38)   78 (39)   27 (50)   
    Unknown   15 (5)   2 (1)   1 (1)   1 (2)   
Specific abnormalities, no. (%)      
    -5 or 5q-   21 (7)   27 (15)   28 (14)   14 (26)   < .001  
    -7 or 7q-   28 (9)   35 (19)   36 (18)   12 (22)   < .001  
    17p   6 (2)   16 (9)   14 (7)   6 (11)   .001  
    t(8;21)   22 (7)   7 (4)   4 (2)   0 (0)   .019  
    inv(16)
 
31 (10)
 
4 (2)
 
7 (4)
 
4 (7)
 
.002
 



Younger than 56 y

56-65 y

66-75 y

Older than 75 y

P*
No. patients   323   183   199   54   
Cytogenetic risk group, no. (%)      < .001 
    Favorable   51 (16)   10 (5)   10 (5)   2 (4)   
    Intermediate   149 (46)   101 (55)   110 (55)   24 (44)   
    Unfavorable   108 (33)   70 (38)   78 (39)   27 (50)   
    Unknown   15 (5)   2 (1)   1 (1)   1 (2)   
Specific abnormalities, no. (%)      
    -5 or 5q-   21 (7)   27 (15)   28 (14)   14 (26)   < .001  
    -7 or 7q-   28 (9)   35 (19)   36 (18)   12 (22)   < .001  
    17p   6 (2)   16 (9)   14 (7)   6 (11)   .001  
    t(8;21)   22 (7)   7 (4)   4 (2)   0 (0)   .019  
    inv(16)
 
31 (10)
 
4 (2)
 
7 (4)
 
4 (7)
 
.002
 

Patients on SWOG trial S0112 are not included. Only patients with evaluable karyotypes are included.

*

Test for heterogeneity among ago groups (age was not treated as a continuous variable for these tests).

Test for patients with known risk group.

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