Clinical features of patients according to the ZPI haplotypes
. | No. . | Age first episode, y, median (range) . | Recurrence, no. (%) . | Other risk factors, no. (%) . | Familial history, no. (%) . |
|---|---|---|---|---|---|
| H1/H1 (reference group) | 297 | 46 (36-60) | 77 (25.9) | 54 (18.2) | 40 (13.5) |
| H1/H2 | 337 | 45 (32-58) | 95 (28.2) | 77 (22.8) | 69 (20.5) |
| H1/H3 | 163 | 45 (32-56) | 46 (28.2) | 42 (25.8) | 21 (12.9) |
| H1/H4 | 3 | 21 (18-65) | 0 | 0 | 0 |
| H1/H5 & H1/H5v | 17 & 1 | 47 (32-62) | 3 (16.7) | 7 (38.9)* | 7 (38.9)* |
| H2/H2 | 90 | 43 (33-59) | 28 (31.1) | 21 (23.3) | 20 (22.2)* |
| H2/H3 | 77 | 45 (34-53) | 19 (24.7) | 13 (16.9) | 12 (15.6) |
| H2/H4 | 5 | 53 (36-67) | 0 | 0 | 1 (20.0) |
| H2/H5 | 9 | 50 (38-65) | 5 (55.6) | 1 (11.1) | 2 (22.2) |
| H3/H3 | 13 | 41 (28-61) | 4 (30.8) | 2 (15.4) | 1 (7.7) |
| H3/H4 | 3 | 29 (25-62) | 0 | 1 (33.3) | 2 (66.7) |
| H3/H5 | 2 | 57 (50-65) | 2 (100) | 0 | 1 (50.0) |
| H5/H5 | 1 | 62 | 1 (100) | 0 | 1 (100) |
| Haplotype carrier | |||||
| H2 | 608 | 45 (33-58) | 147 (28.4) | 111 (21.4) | 104 (20.1)* |
| H3 | 271 | 45 (32-56) | 71 (27.5) | 58 (22.5) | 37 (14.3) |
| H4 | 11 | 44 (25-64) | 0 | 1 (9.1) | 3 (27.3) |
| H5 & H5v | 31 | 46 (32-62) | 11 (36.7) | 9 (30.0) | 11 (36.7)† |
. | No. . | Age first episode, y, median (range) . | Recurrence, no. (%) . | Other risk factors, no. (%) . | Familial history, no. (%) . |
|---|---|---|---|---|---|
| H1/H1 (reference group) | 297 | 46 (36-60) | 77 (25.9) | 54 (18.2) | 40 (13.5) |
| H1/H2 | 337 | 45 (32-58) | 95 (28.2) | 77 (22.8) | 69 (20.5) |
| H1/H3 | 163 | 45 (32-56) | 46 (28.2) | 42 (25.8) | 21 (12.9) |
| H1/H4 | 3 | 21 (18-65) | 0 | 0 | 0 |
| H1/H5 & H1/H5v | 17 & 1 | 47 (32-62) | 3 (16.7) | 7 (38.9)* | 7 (38.9)* |
| H2/H2 | 90 | 43 (33-59) | 28 (31.1) | 21 (23.3) | 20 (22.2)* |
| H2/H3 | 77 | 45 (34-53) | 19 (24.7) | 13 (16.9) | 12 (15.6) |
| H2/H4 | 5 | 53 (36-67) | 0 | 0 | 1 (20.0) |
| H2/H5 | 9 | 50 (38-65) | 5 (55.6) | 1 (11.1) | 2 (22.2) |
| H3/H3 | 13 | 41 (28-61) | 4 (30.8) | 2 (15.4) | 1 (7.7) |
| H3/H4 | 3 | 29 (25-62) | 0 | 1 (33.3) | 2 (66.7) |
| H3/H5 | 2 | 57 (50-65) | 2 (100) | 0 | 1 (50.0) |
| H5/H5 | 1 | 62 | 1 (100) | 0 | 1 (100) |
| Haplotype carrier | |||||
| H2 | 608 | 45 (33-58) | 147 (28.4) | 111 (21.4) | 104 (20.1)* |
| H3 | 271 | 45 (32-56) | 71 (27.5) | 58 (22.5) | 37 (14.3) |
| H4 | 11 | 44 (25-64) | 0 | 1 (9.1) | 3 (27.3) |
| H5 & H5v | 31 | 46 (32-62) | 11 (36.7) | 9 (30.0) | 11 (36.7)† |