Table 2. Pharmacokinetics of rFXIII Dose... | American Society of Hematology

Table 2.

Pharmacokinetics of rFXIII

Dose U/kg	t_½ h	C_o μg/mL	AUC_INF h/μg · mL	CL mL/h · kg	V_ss mL/kg
20
Patient 5	278	3.80	1370	0.103	41.0
Patient 6	213	4.66	984	0.142	45.6
50
Patient 7	8.9	8.58	81.7	4.28	51.5
Patient 8	149	8.24	1430	0.245	50.8
Patient 9	156	9.08	1820	0.193	42.2
75
Patient 10	202	13.6	2450	0.216	58.4
Patient 11	220	11.7	2090	0.253	76.1

Dose U/kg	t_½ h	C_o μg/mL	AUC_INF h/μg · mL	CL mL/h · kg	V_ss mL/kg
20
Patient 5	278	3.80	1370	0.103	41.0
Patient 6	213	4.66	984	0.142	45.6
50
Patient 7	8.9	8.58	81.7	4.28	51.5
Patient 8	149	8.24	1430	0.245	50.8
Patient 9	156	9.08	1820	0.193	42.2
75
Patient 10	202	13.6	2450	0.216	58.4
Patient 11	220	11.7	2090	0.253	76.1

Pharmacokinetic data for patients receiving at least 20 U/kg rFXIII. Patient 6 had normal levels of FXIII before dose, so data were baseline corrected before pharmacokinetic analyses.

Patient 7 had FXIII B subunit deficiency.

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