Grades 3 and 4 nonhematologic toxicities by phase of therapy
. | Induction/intensification, no. of patients . | Reinduction, no. of patients . | Reintensification, no. of patients . | Consolidation, no. of patients . | Intensified maintenance, no. of patient exposures . | Maintenance, no. of patient exposures . |
|---|---|---|---|---|---|---|
| Total | 115 | 91 | 66 | 53 | 120 | 126 |
| Cardiac | ||||||
| Cardiac function | 2 | 0 | 0 | 0 | 0 | 1 |
| Hypertension | 12 | 2 | 1 | 0 | 0 | 1 |
| Hypotension | 9 | 0 | 0 | 0 | 1 | 1 |
| Coagulation | ||||||
| Fibrinogen | 8 | 2 | 0 | 0 | 0 | 1 |
| PT | 7 | 0 | 0 | 2 | 0 | 1 |
| PTT | 10 | 1 | 0 | 1 | 0 | 0 |
| Hemorrhage | 6 | 1 | 0 | 0 | 0 | 0 |
| Gastrointestinal | ||||||
| Stomatitis | 54 | 3 | 10 | 0 | 1 | 4 |
| Abdominal pain | 5 | 1 | 0 | 0 | 0 | 3 |
| Diarrhea | 24 | 9 | 5 | 7 | 9 | 9 |
| Nausea/vomiting | 11 | 1 | 6 | 1 | 2 | 5 |
| Liver | ||||||
| AST | 18 | 1 | 13 | 10 | 3 | 2 |
| ALT | 25 | 4 | 12 | 11 | 8 | 8 |
| Bilirubin | 18 | 2 | 8 | 6 | 1 | 2 |
| Nervous system | ||||||
| Peripheral | 8 | 0 | 0 | 0 | 1 | 4 |
| Central | 5 | 1 | 3 | 0 | 3 | 5 |
| Pancreas | ||||||
| Glucose | 17 | 2 | 2 | 0 | 1 | 2 |
| Pulmonary | ||||||
| PaO2 | 8 | 0 | 0 | 0 | 0 | 0 |
| Functional | 28 | 2 | 2 | 2 | 3 | 2 |
| Clinical | 16 | 0 | 0 | 0 | 1 | 1 |
| Renal | ||||||
| BUN | 6 | 1 | 0 | 0 | 0 | 0 |
| Creatinine clearance | 2 | 1 | 1 | 0 | 0 | 0 |
. | Induction/intensification, no. of patients . | Reinduction, no. of patients . | Reintensification, no. of patients . | Consolidation, no. of patients . | Intensified maintenance, no. of patient exposures . | Maintenance, no. of patient exposures . |
|---|---|---|---|---|---|---|
| Total | 115 | 91 | 66 | 53 | 120 | 126 |
| Cardiac | ||||||
| Cardiac function | 2 | 0 | 0 | 0 | 0 | 1 |
| Hypertension | 12 | 2 | 1 | 0 | 0 | 1 |
| Hypotension | 9 | 0 | 0 | 0 | 1 | 1 |
| Coagulation | ||||||
| Fibrinogen | 8 | 2 | 0 | 0 | 0 | 1 |
| PT | 7 | 0 | 0 | 2 | 0 | 1 |
| PTT | 10 | 1 | 0 | 1 | 0 | 0 |
| Hemorrhage | 6 | 1 | 0 | 0 | 0 | 0 |
| Gastrointestinal | ||||||
| Stomatitis | 54 | 3 | 10 | 0 | 1 | 4 |
| Abdominal pain | 5 | 1 | 0 | 0 | 0 | 3 |
| Diarrhea | 24 | 9 | 5 | 7 | 9 | 9 |
| Nausea/vomiting | 11 | 1 | 6 | 1 | 2 | 5 |
| Liver | ||||||
| AST | 18 | 1 | 13 | 10 | 3 | 2 |
| ALT | 25 | 4 | 12 | 11 | 8 | 8 |
| Bilirubin | 18 | 2 | 8 | 6 | 1 | 2 |
| Nervous system | ||||||
| Peripheral | 8 | 0 | 0 | 0 | 1 | 4 |
| Central | 5 | 1 | 3 | 0 | 3 | 5 |
| Pancreas | ||||||
| Glucose | 17 | 2 | 2 | 0 | 1 | 2 |
| Pulmonary | ||||||
| PaO2 | 8 | 0 | 0 | 0 | 0 | 0 |
| Functional | 28 | 2 | 2 | 2 | 3 | 2 |
| Clinical | 16 | 0 | 0 | 0 | 1 | 1 |
| Renal | ||||||
| BUN | 6 | 1 | 0 | 0 | 0 | 0 |
| Creatinine clearance | 2 | 1 | 1 | 0 | 0 | 0 |
PT indicates prothrombin time; PTT, partial thromboplastin time; AST, aspartate aminotransferase; ALT, alanine aminotransferase; PaO2, oxygen saturation; and BUN, blood urea nitrogen.