Table 2.

Leukemia-free survival (LFS)







LFS rate ± SE, %

Log-rank test*
Hazard ratio
95% CI
97.5% CI
12 mo
24 mo
36 mo
All patients  0.01   0.71   0.54-0.92   0.52-0.96     
Control, n = 160       42 ± 3.9   29 ± 3.6   24 ± 3.4  
HDC/IL-2, n = 160       48 ± 4.0   41 ± 3.9   34 ± 3.8  
Patients in CR1  0.01   0.69   0.51-0.93   0.49-0.97     
Control, n = 132       45 ± 4.3   32 ± 4.1   26 ± 3.8  
HDC/IL-2, n = 129       52 ± 4.4   45 ± 4.4   40 ± 4.4  
Patients in subsequent CR  0.40   0.79   0.43-1.46   0.39-1.60     
Control, n = 28       30 ± 8.8   15 ± 6.9   15 ± 6.9  
HDC/IL-2, n = 31
 

 

 

 

 
29 ± 8.2
 
23 ± 7.5
 
10 ± 5.3
 






LFS rate ± SE, %

Log-rank test*
Hazard ratio
95% CI
97.5% CI
12 mo
24 mo
36 mo
All patients  0.01   0.71   0.54-0.92   0.52-0.96     
Control, n = 160       42 ± 3.9   29 ± 3.6   24 ± 3.4  
HDC/IL-2, n = 160       48 ± 4.0   41 ± 3.9   34 ± 3.8  
Patients in CR1  0.01   0.69   0.51-0.93   0.49-0.97     
Control, n = 132       45 ± 4.3   32 ± 4.1   26 ± 3.8  
HDC/IL-2, n = 129       52 ± 4.4   45 ± 4.4   40 ± 4.4  
Patients in subsequent CR  0.40   0.79   0.43-1.46   0.39-1.60     
Control, n = 28       30 ± 8.8   15 ± 6.9   15 ± 6.9  
HDC/IL-2, n = 31
 

 

 

 

 
29 ± 8.2
 
23 ± 7.5
 
10 ± 5.3
 
*

Statistical analysis using the log-rank test, stratified by country and, if applicable, CR stratum.

Confidence intervals for the hazard ratios of the treatment arms.

LFS rates are Kaplan-Meier estimates at each time point.

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