The 10 most up-regulated and the 10 most down-regulated genes in CD34+ cells of patients with MDS
Affymetrix ID . | Common name . | Map . | No. of patients; n = 55 . | RA; n = 18 . | RARS; n = 19 . | RAEB; n = 18 . |
---|---|---|---|---|---|---|
Most up-regulated | ||||||
203153_at | IFIT1 | 10q25-q26 | 37 | 13 | 15 | 9 |
214022_s_at | IFITM1 | 11p15.5 | 37 | 13 | 11 | 13 |
219777_at | hIAN2 | 7q36.1 | 35 | 12 | 10 | 13 |
209560_s_at | DLK1 | 14q32 | 33 | 9 | 14 | 10 |
228708_at | RAB27B | 18q21.2 | 32 | 10 | 11 | 11 |
206772_at | PTHR2 | 2q33 | 31 | 8 | 12 | 11 |
202382_s_at | GNPDA1 | 5q21 | 30 | 6 | 14 | 10 |
1554242_a_at | COCH | 14q12-q13 | 30 | 8 | 16 | 6 |
221081_s_at | FLJ22457 | 1p13.2 | 30 | 10 | 14 | 6 |
206698_at | XK | xp21.1 | 30 | 10 | 14 | 6 |
Most down-regulated | ||||||
230493_at | TMEM46 | 13q12,13 | 45 | 16 | 13 | 16 |
241679_at | AKAP12 | 6q24-q25 | 44 | 13 | 13 | 18 |
231935_at | ARPP-21 | 3p22.3 | 44 | 13 | 13 | 18 |
221969_at | PAX5 | 9p13 | 43 | 14 | 12 | 17 |
227846_at | GPR | 15q14 | 43 | 14 | 13 | 16 |
210450_at | LOC90925 | 14q32.33 | 43 | 13 | 12 | 18 |
208078_s_at | TCF8 | 10p11.2 | 43 | 16 | 14 | 13 |
220068_at | VPREB3 | 22q11.23 | 43 | 13 | 12 | 18 |
232204_at | EBF | 5q34 | 42 | 13 | 12 | 17 |
203434_s_at | MME | 3q25.1-q25.2 | 42 | 12 | 12 | 18 |
Affymetrix ID . | Common name . | Map . | No. of patients; n = 55 . | RA; n = 18 . | RARS; n = 19 . | RAEB; n = 18 . |
---|---|---|---|---|---|---|
Most up-regulated | ||||||
203153_at | IFIT1 | 10q25-q26 | 37 | 13 | 15 | 9 |
214022_s_at | IFITM1 | 11p15.5 | 37 | 13 | 11 | 13 |
219777_at | hIAN2 | 7q36.1 | 35 | 12 | 10 | 13 |
209560_s_at | DLK1 | 14q32 | 33 | 9 | 14 | 10 |
228708_at | RAB27B | 18q21.2 | 32 | 10 | 11 | 11 |
206772_at | PTHR2 | 2q33 | 31 | 8 | 12 | 11 |
202382_s_at | GNPDA1 | 5q21 | 30 | 6 | 14 | 10 |
1554242_a_at | COCH | 14q12-q13 | 30 | 8 | 16 | 6 |
221081_s_at | FLJ22457 | 1p13.2 | 30 | 10 | 14 | 6 |
206698_at | XK | xp21.1 | 30 | 10 | 14 | 6 |
Most down-regulated | ||||||
230493_at | TMEM46 | 13q12,13 | 45 | 16 | 13 | 16 |
241679_at | AKAP12 | 6q24-q25 | 44 | 13 | 13 | 18 |
231935_at | ARPP-21 | 3p22.3 | 44 | 13 | 13 | 18 |
221969_at | PAX5 | 9p13 | 43 | 14 | 12 | 17 |
227846_at | GPR | 15q14 | 43 | 14 | 13 | 16 |
210450_at | LOC90925 | 14q32.33 | 43 | 13 | 12 | 18 |
208078_s_at | TCF8 | 10p11.2 | 43 | 16 | 14 | 13 |
220068_at | VPREB3 | 22q11.23 | 43 | 13 | 12 | 18 |
232204_at | EBF | 5q34 | 42 | 13 | 12 | 17 |
203434_s_at | MME | 3q25.1-q25.2 | 42 | 12 | 12 | 18 |
The genes are ranked by number of patients showing up-regulation (ratio > 2.0) or down-regulation (ratio < 0.5). The breakdown according to FAB subtype of patients showing up- or down-regulation is also indicated.