The most significant genes expressed at higher or lower levels in MDS del(5q)
Affymetrix ID . | Common . | P . | MDS del5q . | MDS normal . | MDS other . | Map . |
|---|---|---|---|---|---|---|
| Genes expressed at higher levels in MDS del(5q) | ||||||
| 213513_x_at | ARPC2 | < .001 | 1.26 (1.05-1.62) | 0.96 (0.72-1.16) | 1.00 (0.84-1.18) | 2q36.1 |
| 208496_x_at | HIST1H3G | < .001 | 1.42 (0.91-2.35) | 0.87 (0.56-1.31) | 0.87 (0.70-1.04) | 6p21.3 |
| 208180_s_at | HIST1H4H | < .001 | 9.03 (0.91-71.12) | 1.13 (0.54-3.22) | 0.92 (0.63-1.54) | 6p21.3 |
| 201938_at | CDK2AP1 | < .001 | 1.60 (1.17-2.38) | 1.02 (0.39-1.43) | 1.03 (0.56-1.34) | 12q24.31 |
| 214469_at | HIST1H2AE | < .001 | 6.38 (1.09-46.71) | 1.11 (0.57-3.10) | 0.90 (0.41-1.62) | 6p22.2-p21.1 |
| 202746_at | ITM2A | < .001 | 1.97 (1.22-3.92) | 1.16 (0.70-2.33) | 1.21 (0.67-2.07) | Xq13.3-Xq21.2 |
| 221676_s_at | CORO1C | < .001 | 1.86 (1.08-3.37) | 0.93 (0.35-1.65) | 0.93 (0.67-1.33) | 12q24.1 |
| 201312_s_at | SH3BGRL | < .001 | 1.28 (0.87-1.75) | 0.96 (0.77-1.22) | 0.97 (0.88-1.10) | xq13.3 |
| 214472_at | HIST1H3D | < .001 | 4.14 (1.60-25.44) | 1.15 (0.54-6.90) | 1.16 (0.50-5.23) | 6p21.3 |
| 235479_at | CPEB2 | < .001 | 1.39 (0.71-3.18) | 0.91 (0.58-1.33) | 0.71 (0.55-0.89) | 4p15.33 |
| 206110_at | HIST1H3H | < .001 | 11.43 (2.19-120.60) | 1.16 (0.60-2.75) | 0.92 (0.49-2.05) | 6p22-p21.3 |
| 238199_x_at | MYBPC3 | < .001 | 1.28 (0.65-1.90) | 0.89 (0.59-1.19) | 0.80 (0.64-0.93) | 11p11.2 |
| 215779_s_at | HIST1H2BC | < .001 | 3.64 (1.15-17.89) | 1.19 (0.75-2.71) | 0.97 (0.65-1.72) | 6p21.3 |
| 208579_x_at | HIST1H2BM | < .001 | 5.46 (1.23-25.16) | 1.35 (0.77-3.26) | 1.45 (0.34-5.23) | 6p22-p21.3 |
| 223144_s_at | C6orf166 | < .001 | 1.49 (0.73-5.00) | 0.92 (0.35-1.91) | 0.77 (0.60-0.99) | 6q15 |
| 212082_s_at | MYL6 | < .001 | 1.28 (0.90-1.97) | 0.94 (0.70-1.14) | 0.92 (0.79-1.08) | 12q13.13 |
| 238585_at | FLJ11753 | < .001 | 1.18 (0.79-1.61) | 0.84 (0.59-1.13) | 0.92 (0.71-1.20) | 2q22.3-q23.1 |
| 202821_s_at | LPP | .001 | 1.20 (0.76-1.86) | 0.98 (0.73-1.48) | 0.84 (0.74-0.98) | 3q27-q28 |
| 221613_s_at | AWP1 | .001 | 1.26 (0.82-1.80) | 0.95 (0.70-1.21) | 0.85 (0.63-0.99) | 15q24.3 |
| 201238_s_at | CAPZA2 | .001 | 1.79 (1.22-3.08) | 1.19 (0.77-1.67) | 1.13 (0.75-1.63) | 7q31.2-q31.3 |
| Genes, localized to 5q, expressed at lower levels in MDS del(5q) | ||||||
| 203538_at | CAMLG | < .001 | 0.53 (0.36-0.85) | 1.13 (0.84-1.52) | 1.15 (0.58-1.78) | 5q23 |
| 203024_s_at | C5orf15 | < .001 | 0.53 (0.36-0.77) | 1.02 (0.81-1.35) | 1.01 (0.77-1.32) | 5q31.1 |
| 220495_s_at | C5orf14 | < .001 | 0.45 (0.28-0.95) | 1.10 (0.56-1.60) | 1.14 (0.85-1.73) | 5q31.2 |
| 224068_x_at | RBM22 | < .001 | 0.54 (0.29-1.08) | 1.21 (0.79-1.82) | 1.41 (1.08-1.90) | 5q33.1 |
| 202227_s_at | BRD8 | < .001 | 0.63 (0.40-1.04) | 1.25 (0.80-1.66) | 1.19 (0.79-2.04) | 5q31 |
| 206562_s_at | CSNK1A1 | < .001 | 0.60 (0.36-0.93) | 1.06 (0.65-1.38) | 1.09 (0.76-1.29) | 5q32 |
| 201977_s_at | KIAA0141 | < .001 | 0.71 (0.46-1.18) | 1.23 (0.66-1.89) | 1.45 (1.17-2.01) | 5q31.3 |
| 225698_at | TIGA1 | < .001 | 0.43 (0.19-1.04) | 1.23 (0.81-2.24) | 1.37 (0.66-1.80) | 5q21-q22 |
| 232181_at | LOC153346 | < .001 | 0.57 (0.28-1.08) | 1.23 (0.63-2.03) | 1.31 (1.05-1.97) | 5q33.1 |
| 202042_at | HARS | < .001 | 0.52 (0.28-0.85) | 1.16 (0.76-1.50) | 1.21 (0.65-1.76) | 5q31.3 |
| Genes, not localized to 5q, expressed at lower levels in MDS del(5q) | ||||||
| 223157_at | C4orf14 | < .001 | 0.64 (0.25-1.07) | 1.44 (0.88-2.86) | 1.59 (0.98-2.84) | 4q12 |
| 1556967_at | ZDHHC14 | < .001 | 0.84 (0.73-1.01) | 1.17 (0.87-1.61) | 0.95 (0.81-1.30) | 6q25.3 |
| 207170_s_at | HCCR1 | < .001 | 0.86 (0.52-1.35) | 1.63 (0.89-2.74) | 1.62 (1.02-2.32) | 12q13.13 |
| 228557_at | FLJ35936 | < .001 | 0.63 (0.30-1.50) | 1.47 (0.81-3.62) | 1.50 (0.90-2.30) | 18p11.31-p11.23 |
| 202080_s_at | OIP106 | < .001 | 0.75 (0.44-1.21) | 1.17 (0.79-1.82) | 1.23 (1.02-1.39) | 3p25.3-p24.1 |
| 206019_at | RBM19 | < .001 | 0.79 (0.58-1.21) | 1.22 (0.80-1.89) | 1.13 (0.90-1.68) | 12q24.21 |
| 201871_s_at | LOC51035 | < .001 | 0.70 (0.43-1.17) | 1.25 (0.73-2.03) | 1.41 (0.88-2.07) | 11q12.3 |
| 205321_at | EIF2S3 | < .001 | 0.78 (0.47-1.29) | 1.32 (0.71-2.30) | 1.63 (1.03-2.88) | Xp22.2-p22.1 |
| 201682_at | PMPCB | < .001 | 0.71 (0.47-0.98) | 1.02 (0.81-1.21) | 0.96 (0.62-1.19) | 7q22-q32 |
| 212307_s_at | OGT | < .001 | 0.49 (0.24-0.83) | 1.04 (0.58-2.51) | 0.94 (0.62-1.97) | Xq13 |
Affymetrix ID . | Common . | P . | MDS del5q . | MDS normal . | MDS other . | Map . |
|---|---|---|---|---|---|---|
| Genes expressed at higher levels in MDS del(5q) | ||||||
| 213513_x_at | ARPC2 | < .001 | 1.26 (1.05-1.62) | 0.96 (0.72-1.16) | 1.00 (0.84-1.18) | 2q36.1 |
| 208496_x_at | HIST1H3G | < .001 | 1.42 (0.91-2.35) | 0.87 (0.56-1.31) | 0.87 (0.70-1.04) | 6p21.3 |
| 208180_s_at | HIST1H4H | < .001 | 9.03 (0.91-71.12) | 1.13 (0.54-3.22) | 0.92 (0.63-1.54) | 6p21.3 |
| 201938_at | CDK2AP1 | < .001 | 1.60 (1.17-2.38) | 1.02 (0.39-1.43) | 1.03 (0.56-1.34) | 12q24.31 |
| 214469_at | HIST1H2AE | < .001 | 6.38 (1.09-46.71) | 1.11 (0.57-3.10) | 0.90 (0.41-1.62) | 6p22.2-p21.1 |
| 202746_at | ITM2A | < .001 | 1.97 (1.22-3.92) | 1.16 (0.70-2.33) | 1.21 (0.67-2.07) | Xq13.3-Xq21.2 |
| 221676_s_at | CORO1C | < .001 | 1.86 (1.08-3.37) | 0.93 (0.35-1.65) | 0.93 (0.67-1.33) | 12q24.1 |
| 201312_s_at | SH3BGRL | < .001 | 1.28 (0.87-1.75) | 0.96 (0.77-1.22) | 0.97 (0.88-1.10) | xq13.3 |
| 214472_at | HIST1H3D | < .001 | 4.14 (1.60-25.44) | 1.15 (0.54-6.90) | 1.16 (0.50-5.23) | 6p21.3 |
| 235479_at | CPEB2 | < .001 | 1.39 (0.71-3.18) | 0.91 (0.58-1.33) | 0.71 (0.55-0.89) | 4p15.33 |
| 206110_at | HIST1H3H | < .001 | 11.43 (2.19-120.60) | 1.16 (0.60-2.75) | 0.92 (0.49-2.05) | 6p22-p21.3 |
| 238199_x_at | MYBPC3 | < .001 | 1.28 (0.65-1.90) | 0.89 (0.59-1.19) | 0.80 (0.64-0.93) | 11p11.2 |
| 215779_s_at | HIST1H2BC | < .001 | 3.64 (1.15-17.89) | 1.19 (0.75-2.71) | 0.97 (0.65-1.72) | 6p21.3 |
| 208579_x_at | HIST1H2BM | < .001 | 5.46 (1.23-25.16) | 1.35 (0.77-3.26) | 1.45 (0.34-5.23) | 6p22-p21.3 |
| 223144_s_at | C6orf166 | < .001 | 1.49 (0.73-5.00) | 0.92 (0.35-1.91) | 0.77 (0.60-0.99) | 6q15 |
| 212082_s_at | MYL6 | < .001 | 1.28 (0.90-1.97) | 0.94 (0.70-1.14) | 0.92 (0.79-1.08) | 12q13.13 |
| 238585_at | FLJ11753 | < .001 | 1.18 (0.79-1.61) | 0.84 (0.59-1.13) | 0.92 (0.71-1.20) | 2q22.3-q23.1 |
| 202821_s_at | LPP | .001 | 1.20 (0.76-1.86) | 0.98 (0.73-1.48) | 0.84 (0.74-0.98) | 3q27-q28 |
| 221613_s_at | AWP1 | .001 | 1.26 (0.82-1.80) | 0.95 (0.70-1.21) | 0.85 (0.63-0.99) | 15q24.3 |
| 201238_s_at | CAPZA2 | .001 | 1.79 (1.22-3.08) | 1.19 (0.77-1.67) | 1.13 (0.75-1.63) | 7q31.2-q31.3 |
| Genes, localized to 5q, expressed at lower levels in MDS del(5q) | ||||||
| 203538_at | CAMLG | < .001 | 0.53 (0.36-0.85) | 1.13 (0.84-1.52) | 1.15 (0.58-1.78) | 5q23 |
| 203024_s_at | C5orf15 | < .001 | 0.53 (0.36-0.77) | 1.02 (0.81-1.35) | 1.01 (0.77-1.32) | 5q31.1 |
| 220495_s_at | C5orf14 | < .001 | 0.45 (0.28-0.95) | 1.10 (0.56-1.60) | 1.14 (0.85-1.73) | 5q31.2 |
| 224068_x_at | RBM22 | < .001 | 0.54 (0.29-1.08) | 1.21 (0.79-1.82) | 1.41 (1.08-1.90) | 5q33.1 |
| 202227_s_at | BRD8 | < .001 | 0.63 (0.40-1.04) | 1.25 (0.80-1.66) | 1.19 (0.79-2.04) | 5q31 |
| 206562_s_at | CSNK1A1 | < .001 | 0.60 (0.36-0.93) | 1.06 (0.65-1.38) | 1.09 (0.76-1.29) | 5q32 |
| 201977_s_at | KIAA0141 | < .001 | 0.71 (0.46-1.18) | 1.23 (0.66-1.89) | 1.45 (1.17-2.01) | 5q31.3 |
| 225698_at | TIGA1 | < .001 | 0.43 (0.19-1.04) | 1.23 (0.81-2.24) | 1.37 (0.66-1.80) | 5q21-q22 |
| 232181_at | LOC153346 | < .001 | 0.57 (0.28-1.08) | 1.23 (0.63-2.03) | 1.31 (1.05-1.97) | 5q33.1 |
| 202042_at | HARS | < .001 | 0.52 (0.28-0.85) | 1.16 (0.76-1.50) | 1.21 (0.65-1.76) | 5q31.3 |
| Genes, not localized to 5q, expressed at lower levels in MDS del(5q) | ||||||
| 223157_at | C4orf14 | < .001 | 0.64 (0.25-1.07) | 1.44 (0.88-2.86) | 1.59 (0.98-2.84) | 4q12 |
| 1556967_at | ZDHHC14 | < .001 | 0.84 (0.73-1.01) | 1.17 (0.87-1.61) | 0.95 (0.81-1.30) | 6q25.3 |
| 207170_s_at | HCCR1 | < .001 | 0.86 (0.52-1.35) | 1.63 (0.89-2.74) | 1.62 (1.02-2.32) | 12q13.13 |
| 228557_at | FLJ35936 | < .001 | 0.63 (0.30-1.50) | 1.47 (0.81-3.62) | 1.50 (0.90-2.30) | 18p11.31-p11.23 |
| 202080_s_at | OIP106 | < .001 | 0.75 (0.44-1.21) | 1.17 (0.79-1.82) | 1.23 (1.02-1.39) | 3p25.3-p24.1 |
| 206019_at | RBM19 | < .001 | 0.79 (0.58-1.21) | 1.22 (0.80-1.89) | 1.13 (0.90-1.68) | 12q24.21 |
| 201871_s_at | LOC51035 | < .001 | 0.70 (0.43-1.17) | 1.25 (0.73-2.03) | 1.41 (0.88-2.07) | 11q12.3 |
| 205321_at | EIF2S3 | < .001 | 0.78 (0.47-1.29) | 1.32 (0.71-2.30) | 1.63 (1.03-2.88) | Xp22.2-p22.1 |
| 201682_at | PMPCB | < .001 | 0.71 (0.47-0.98) | 1.02 (0.81-1.21) | 0.96 (0.62-1.19) | 7q22-q32 |
| 212307_s_at | OGT | < .001 | 0.49 (0.24-0.83) | 1.04 (0.58-2.51) | 0.94 (0.62-1.97) | Xq13 |
The average ratio and range is shown for each gene in the MDS del(5q), MDS with a normal karyotype, and MDS with other karyotype groups.