Proteinase association with integrins
Soluble proteases/associated proteins . | Cell-surface expression . | Source . |
|---|---|---|
| MMPs | ||
| MMP-1 | ||
| α1β1 | Myocytes | Stricker et al24 |
| α2β1 | Keratinocytes | Dumin et al25 |
| EMMPRIN | Lung carcinoma | Guo et al26 |
| PAR1 | Breast carcinoma | Boire et al27 |
| MMP-2 | ||
| αVβ3 | Melanoma, endothelial | Brooks et al28 |
| LRP | Fibroblasts | Yang et al29 |
| Collagen chains | Fibroblasts | Steffensen et al30 |
| TSP-2 | Fibroblasts | Yang et al29 |
| TIMP-2 | Malignant cells | Olson et al31 |
| Caveolin-1 | Endothelial | Puyraimond et al32 |
| Hsp90α | Fibrosarcoma | Eustace et al33 |
| MT1-MMP | Fibrosarcoma | Strongin et al34 |
| BS | – | Fedarko et al35 |
| MMP-3 | ||
| Osteopontin | – | Fedarko et al35 |
| MMP-7 | ||
| CD44HSPG | Epithelial | Yu et al36 |
| TM4SF | – | Maecker et al37 |
| CD151 | Rectal carcinoma | Shiomi et al38 |
| MMP-9 | ||
| Collagen chains | Epithelial/fibrosarcoma | Okada et al39 |
| RECK | Fibrosarcoma | Takahashi et al40 |
| CD44 | Melanoma | Yu et al41 |
| ICAM-1 | Leukemias | Fiore et al42 |
| LRP | Fibroblasts | Hahn-Dantona et al43 |
| Ku protein | Macrophages/leukemia | Monferran et al44 |
| TIMP-1 | Fibroblasts | O'Connell et al45 |
| TSP-1 | Malignant cells | Rodriguez-Mazaneque et al46 |
| αL/Mβ2 | Neutrophils/leukemias | Stefanidakis et al47 |
| α5β1 | Epithelial | Wang et al48 |
| α3β1 | Mammary carcinoma | Morini et al49 |
| αVβ5 | Fibrosarcoma | Bjorklund et al50 |
| DMP-1 | – | Fedarko et al35 |
| MT1-MMP | ||
| αVβ3 | Endothelial | Galvez et al51 |
| β1-subunit | Endothelial | Galvez et al51 |
| CD44 | Fibrosarcoma | Mori et al52 |
| TIMP-2 | Breast carcinoma | Imai et al53 |
| Collagen type I | Gingival fibroblasts | Tam et al54 |
| RECK | Fibrosarcoma | Oh et al55 |
| Serine proteases | ||
| uPA | ||
| uPAR* | Malignant | Ellis et al56 |
| αM/Xβ2 | Neutrophils | Xue et al57 |
| αVβ3 | Fibrosarcoma | Xue et al58 |
| αVβ5 | Mammary carcinoma | Carriero et al59 |
| α3β1 | Mammary carcinoma | Wei et al60 |
| Elastase | ||
| αMβ2 | Neutrophils | Cai and Wright61 |
| Seprase | ||
| uPAR | Melanoma | Artym et al62 |
| α3β1 | Melanoma | Monsky et al63 |
| Dipeptidyl peptidase IV | ||
| α3β1 | Fibroblasts | Ghersi et al64 |
| Cathepsin G | ||
| FPR | Leukemias | Sun et al65 |
| HIV-1 gp120 | Leukemias | Avril et al66 |
| Membrane Gp | Platelets/neutrophils | Molino et al67 |
| Proteinase 3 | ||
| αMβ2 | Neutrophils | David et al68 |
| Plasmin | ||
| Annexin II | Kidney cells | MacLeod et al69 |
| Cysteine proteases | ||
| Cathepsin B | ||
| Annexin II | Tumors | Mai et al70 |
| α2-M | Bone metastases | Arkona et al71 |
| Caspase-8 | ||
| α3β1 | Neuroblastoma | Stupack et al72 |
| ADAMs | ||
| ADAM-2 | ||
| α6β1 | Oocytes | Chen et al73 |
| ADAM-7 | ||
| α4β1 | T-cell leukemia | Bridges et al74 |
| α9β1 | T-cell leukemia | Bridges et al74 |
| α4β7 | T-cell leukemia | Bridges et al74 |
| ADAM-9 | ||
| α6β1 | Fibroblasts | Nath et al75 |
| α9β1 | Oocytes | Eto et al76 |
| αvβ5 | Myeloma | Zhou et al77 |
| ADAM-12 | ||
| α9β1 | Hematopoietic | Zhang et al78 |
| ADAM-15 | ||
| αVβ3 | Hematopoietic | Nath et al79 |
| α5β1 | Hematopoietic | Nath et al79 |
| α9β1 | Oocytes | Eto et al76 |
| ADAM-17 | ||
| α5β1 | Epithelial | Bax et al80 |
| ADAM-23 | ||
| αVβ3 | Neuroblastoma | Cal et al81 |
| ADAM-28 | ||
| α4β1 | Lymphocytes | Bridges et al74 |
| α9β1 | T-cell leukemia | Bridges et al74 |
| α4β7 | T-cell leukemia | Bridges et al74 |
| ADAM-33 | ||
| α9β1 | T-cell leukemia | Bridges et al74 |
Soluble proteases/associated proteins . | Cell-surface expression . | Source . |
|---|---|---|
| MMPs | ||
| MMP-1 | ||
| α1β1 | Myocytes | Stricker et al24 |
| α2β1 | Keratinocytes | Dumin et al25 |
| EMMPRIN | Lung carcinoma | Guo et al26 |
| PAR1 | Breast carcinoma | Boire et al27 |
| MMP-2 | ||
| αVβ3 | Melanoma, endothelial | Brooks et al28 |
| LRP | Fibroblasts | Yang et al29 |
| Collagen chains | Fibroblasts | Steffensen et al30 |
| TSP-2 | Fibroblasts | Yang et al29 |
| TIMP-2 | Malignant cells | Olson et al31 |
| Caveolin-1 | Endothelial | Puyraimond et al32 |
| Hsp90α | Fibrosarcoma | Eustace et al33 |
| MT1-MMP | Fibrosarcoma | Strongin et al34 |
| BS | – | Fedarko et al35 |
| MMP-3 | ||
| Osteopontin | – | Fedarko et al35 |
| MMP-7 | ||
| CD44HSPG | Epithelial | Yu et al36 |
| TM4SF | – | Maecker et al37 |
| CD151 | Rectal carcinoma | Shiomi et al38 |
| MMP-9 | ||
| Collagen chains | Epithelial/fibrosarcoma | Okada et al39 |
| RECK | Fibrosarcoma | Takahashi et al40 |
| CD44 | Melanoma | Yu et al41 |
| ICAM-1 | Leukemias | Fiore et al42 |
| LRP | Fibroblasts | Hahn-Dantona et al43 |
| Ku protein | Macrophages/leukemia | Monferran et al44 |
| TIMP-1 | Fibroblasts | O'Connell et al45 |
| TSP-1 | Malignant cells | Rodriguez-Mazaneque et al46 |
| αL/Mβ2 | Neutrophils/leukemias | Stefanidakis et al47 |
| α5β1 | Epithelial | Wang et al48 |
| α3β1 | Mammary carcinoma | Morini et al49 |
| αVβ5 | Fibrosarcoma | Bjorklund et al50 |
| DMP-1 | – | Fedarko et al35 |
| MT1-MMP | ||
| αVβ3 | Endothelial | Galvez et al51 |
| β1-subunit | Endothelial | Galvez et al51 |
| CD44 | Fibrosarcoma | Mori et al52 |
| TIMP-2 | Breast carcinoma | Imai et al53 |
| Collagen type I | Gingival fibroblasts | Tam et al54 |
| RECK | Fibrosarcoma | Oh et al55 |
| Serine proteases | ||
| uPA | ||
| uPAR* | Malignant | Ellis et al56 |
| αM/Xβ2 | Neutrophils | Xue et al57 |
| αVβ3 | Fibrosarcoma | Xue et al58 |
| αVβ5 | Mammary carcinoma | Carriero et al59 |
| α3β1 | Mammary carcinoma | Wei et al60 |
| Elastase | ||
| αMβ2 | Neutrophils | Cai and Wright61 |
| Seprase | ||
| uPAR | Melanoma | Artym et al62 |
| α3β1 | Melanoma | Monsky et al63 |
| Dipeptidyl peptidase IV | ||
| α3β1 | Fibroblasts | Ghersi et al64 |
| Cathepsin G | ||
| FPR | Leukemias | Sun et al65 |
| HIV-1 gp120 | Leukemias | Avril et al66 |
| Membrane Gp | Platelets/neutrophils | Molino et al67 |
| Proteinase 3 | ||
| αMβ2 | Neutrophils | David et al68 |
| Plasmin | ||
| Annexin II | Kidney cells | MacLeod et al69 |
| Cysteine proteases | ||
| Cathepsin B | ||
| Annexin II | Tumors | Mai et al70 |
| α2-M | Bone metastases | Arkona et al71 |
| Caspase-8 | ||
| α3β1 | Neuroblastoma | Stupack et al72 |
| ADAMs | ||
| ADAM-2 | ||
| α6β1 | Oocytes | Chen et al73 |
| ADAM-7 | ||
| α4β1 | T-cell leukemia | Bridges et al74 |
| α9β1 | T-cell leukemia | Bridges et al74 |
| α4β7 | T-cell leukemia | Bridges et al74 |
| ADAM-9 | ||
| α6β1 | Fibroblasts | Nath et al75 |
| α9β1 | Oocytes | Eto et al76 |
| αvβ5 | Myeloma | Zhou et al77 |
| ADAM-12 | ||
| α9β1 | Hematopoietic | Zhang et al78 |
| ADAM-15 | ||
| αVβ3 | Hematopoietic | Nath et al79 |
| α5β1 | Hematopoietic | Nath et al79 |
| α9β1 | Oocytes | Eto et al76 |
| ADAM-17 | ||
| α5β1 | Epithelial | Bax et al80 |
| ADAM-23 | ||
| αVβ3 | Neuroblastoma | Cal et al81 |
| ADAM-28 | ||
| α4β1 | Lymphocytes | Bridges et al74 |
| α9β1 | T-cell leukemia | Bridges et al74 |
| α4β7 | T-cell leukemia | Bridges et al74 |
| ADAM-33 | ||
| α9β1 | T-cell leukemia | Bridges et al74 |
Many of the functions and binding mechanisms of these complexes have not yet been elucidated.
PAR1 indicates protease-activated receptor 1; Hsp, heat shock protein; BS, bone sialoprotein; HSPG, heparan sulfate proteoglycans; RECK reversion-inducing cysteine-rich protein with kazal motifs; DMP-1, dentin matrix protein-1; FPR, formyl peptide receptor; α2-M, α2-macroglobulin; ADAM, a disintegrin and metalloproteinase; Gp, membrane glycoproteins; and –, not studied
uPAR, in turn, interacts with αM/Xβ2, αVβ3, αVβ5, and α3β1