Table 2.

Peripheral blood and bone marrow requirements for complete (CR) and partial (PR) remissions as well as other remission categories in myelofibrosis with myeloid metaplasia (MMM) and myelodysplastic syndrome (MDS)

IWG-MMM
IWG-MDS
EUMNET-MMM
Response category
Peripheral blood
Bone marrow
Peripheral blood
Bone marrow
Peripheral blood
Bone marrow
Complete remission (CR)   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L All counts ≤ upper normal limit No blasts or immature cells   Blasts ≤ 5% Fibrosis grade ≤ 1 Normocellular   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L No blasts   Blasts ≤ 5% Dysplasia allowed   N/A   N/A  
Partial remission (PR)   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L All counts ≤ upper normal limit No blasts or immature cells   Not relevant   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L No blasts   Blasts > 5% but ≥ 50% ↓ in number   N/A   N/A  
Marrow CR   N/A   N/A   Not relevant   Blasts ≤ 5% and ≥ 50% ↓ in number Dysplasia allowed   N/A   N/A  
Clinical improvement  Table 1   Not relevant   N/A   N/A   N/A   N/A  
Hematologic improvement   N/A   N/A   Cheson et al32   Not relevant   N/A   N/A  
Complete response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Major response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Moderate response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Minor response
 		 N/A
 		 N/A
 		 N/A
 		 N/A
 		Table 3 
 		 Not relevant
 
IWG-MMM
IWG-MDS
EUMNET-MMM
Response category
Peripheral blood
Bone marrow
Peripheral blood
Bone marrow
Peripheral blood
Bone marrow
Complete remission (CR)   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L All counts ≤ upper normal limit No blasts or immature cells   Blasts ≤ 5% Fibrosis grade ≤ 1 Normocellular   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L No blasts   Blasts ≤ 5% Dysplasia allowed   N/A   N/A  
Partial remission (PR)   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L All counts ≤ upper normal limit No blasts or immature cells   Not relevant   Hgb ≥ 110 g/L Platelets ≥ 100 × 109/L Neutrophils ≥ 1.0 × 109/L No blasts   Blasts > 5% but ≥ 50% ↓ in number   N/A   N/A  
Marrow CR   N/A   N/A   Not relevant   Blasts ≤ 5% and ≥ 50% ↓ in number Dysplasia allowed   N/A   N/A  
Clinical improvement  Table 1   Not relevant   N/A   N/A   N/A   N/A  
Hematologic improvement   N/A   N/A   Cheson et al32   Not relevant   N/A   N/A  
Complete response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Major response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Moderate response   N/A   N/A   N/A   N/A  Table 3   Not relevant  
Minor response
 		 N/A
 		 N/A
 		 N/A
 		 N/A
 		Table 3 
 		 Not relevant
 

The International Working Group (IWG) response criteria for MMM and MDS are compared with each other as well as with the criteria set by the European Myelofibrosis Network (EUMNET) for MMM.

Hgb indicates hemoglobin level; N/A, not applicable

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