Factors indicating negative OAL prognosis
Reference, year . | No. of patients . | Histoligic subtype of lymphoma . | Univariate analysis . | CSS/DFS Cox proportional hazards model . | OS, Cox proportional hazards model . |
|---|---|---|---|---|---|
| Bessell et al,13 1988 | 115 | Ocular adnexa | High grade | – | – |
| White et al,36 1995 | 42 | Ocular adnexa | Secondary NHL | – | – |
| Esik et al,18 1996 | 37 | Orbital | Older age; advanced stage; high grade | – | – |
| Bolek et al,20 1999 | 38 | Orbital | High grade | – | – |
| Nakata et al,39 1999 | 57 | Ocular adnexa | Non-MALT type; LDH > N; advanced stage | CSS; LDH > N; Non-MALT type | – |
| Jenkins et al,40 2000 | 192 | Ocular adnexa | High grade | – | – |
| Auw-Haedrich et al,41 2001 | 46 | Ocular adnexa | Advanced stage; high grade; p53 expression | – | – |
| Sasai et al,46 2001 | 41 | Ocular adnexa | High grade | – | – |
| Stafford et al,22 2001 | 55 | Orbital | Advanced stage | – | – |
| Cho et al,42 2003 | 68 | Ocular adnexa | Non-MALT type | – | – |
| Fung et al,43 2003 | 98 | Ocular adnexa | Advanced stage | – | – |
| Martinet et al,27 2003 | 90 | Orbital | Age > 64; high grade; ESR > N; muscle infiltration; nonconjunctival site; LDH > N | DFS; age > 64; high grade; ESR > N; nonconjunctival site; LDH > N | Age > 64; high grade |
| Zucca et al,88 2003 | 31 | MALT type | Advanced stage; LDH > N; extranodal site > 1; nodal involvement; IPI score > 2 | CSS; nodal involvement; PFS; IPI score > 2 | Advanced stage |
| Coupland et al,10 2004 | 230 | Ocular adnexa | Age > 60; high grade; advanced stage; p21, p53, and pRB positivity | CSS; age > 60; high grade; advanced stage | – |
| Meunier et al,11 2004 | 145 | Ocular adnexa | High grade; age > 60*; nodal involvement,*; LDH > N*; IPI score > 2* | DFS; age > 60; advanced stage; LDH > N | High grade; B symptoms; age > 60; advanced stage; LDH > N |
| Rosado et al,30 2006 | 62 | Ocular adnexa | Advanced stage | – | – |
Reference, year . | No. of patients . | Histoligic subtype of lymphoma . | Univariate analysis . | CSS/DFS Cox proportional hazards model . | OS, Cox proportional hazards model . |
|---|---|---|---|---|---|
| Bessell et al,13 1988 | 115 | Ocular adnexa | High grade | – | – |
| White et al,36 1995 | 42 | Ocular adnexa | Secondary NHL | – | – |
| Esik et al,18 1996 | 37 | Orbital | Older age; advanced stage; high grade | – | – |
| Bolek et al,20 1999 | 38 | Orbital | High grade | – | – |
| Nakata et al,39 1999 | 57 | Ocular adnexa | Non-MALT type; LDH > N; advanced stage | CSS; LDH > N; Non-MALT type | – |
| Jenkins et al,40 2000 | 192 | Ocular adnexa | High grade | – | – |
| Auw-Haedrich et al,41 2001 | 46 | Ocular adnexa | Advanced stage; high grade; p53 expression | – | – |
| Sasai et al,46 2001 | 41 | Ocular adnexa | High grade | – | – |
| Stafford et al,22 2001 | 55 | Orbital | Advanced stage | – | – |
| Cho et al,42 2003 | 68 | Ocular adnexa | Non-MALT type | – | – |
| Fung et al,43 2003 | 98 | Ocular adnexa | Advanced stage | – | – |
| Martinet et al,27 2003 | 90 | Orbital | Age > 64; high grade; ESR > N; muscle infiltration; nonconjunctival site; LDH > N | DFS; age > 64; high grade; ESR > N; nonconjunctival site; LDH > N | Age > 64; high grade |
| Zucca et al,88 2003 | 31 | MALT type | Advanced stage; LDH > N; extranodal site > 1; nodal involvement; IPI score > 2 | CSS; nodal involvement; PFS; IPI score > 2 | Advanced stage |
| Coupland et al,10 2004 | 230 | Ocular adnexa | Age > 60; high grade; advanced stage; p21, p53, and pRB positivity | CSS; age > 60; high grade; advanced stage | – |
| Meunier et al,11 2004 | 145 | Ocular adnexa | High grade; age > 60*; nodal involvement,*; LDH > N*; IPI score > 2* | DFS; age > 60; advanced stage; LDH > N | High grade; B symptoms; age > 60; advanced stage; LDH > N |
| Rosado et al,30 2006 | 62 | Ocular adnexa | Advanced stage | – | – |
Cox proportional hazards model was used for multivariate analysis
ESR, erythrocyte sedimentation rate; CSS, cause-specific survival
Univariate analysis was performed on patients with low-grade lymphoma