Multivariate Cox proportional hazards analysis in newly diagnosed MM
. | . | Event-free survival . | . | . | Overall survival . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | % . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||
| Amp1q21 | 42 | 1.86 | 1.34, 2.57 | < .001 | 1.78 | 1.19, 2.68 | .005 | ||||
| del(13)* | 24 | 1.49 | 1.03, 2.14 | .034 | 1.64 | 1.05, 2.56 | .031 | ||||
| CA | 34 | 1.51 | 1.09, 2.09 | .014 | 1.82 | 1.22, 2.71 | .003 | ||||
| B2M level, 3.5 mg/L or more | 34 | 1.35 | 0.96, 1.88 | .081 | 1.35 | 0.90, 2.04 | .145 | ||||
| LDH level, 190 IU/L or more | 29 | 1.39 | 0.99, 1.95 | .057 | 1.46 | 0.96, 2.22 | .074 | ||||
| ALB level, less than 3.5 g/dL | 34 | 1.32 | 0.96, 1.81 | .083 | 1.45 | 0.99, 2.13 | .059 | ||||
. | . | Event-free survival . | . | . | Overall survival . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | % . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||
| Amp1q21 | 42 | 1.86 | 1.34, 2.57 | < .001 | 1.78 | 1.19, 2.68 | .005 | ||||
| del(13)* | 24 | 1.49 | 1.03, 2.14 | .034 | 1.64 | 1.05, 2.56 | .031 | ||||
| CA | 34 | 1.51 | 1.09, 2.09 | .014 | 1.82 | 1.22, 2.71 | .003 | ||||
| B2M level, 3.5 mg/L or more | 34 | 1.35 | 0.96, 1.88 | .081 | 1.35 | 0.90, 2.04 | .145 | ||||
| LDH level, 190 IU/L or more | 29 | 1.39 | 0.99, 1.95 | .057 | 1.46 | 0.96, 2.22 | .074 | ||||
| ALB level, less than 3.5 g/dL | 34 | 1.32 | 0.96, 1.81 | .083 | 1.45 | 0.99, 2.13 | .059 | ||||
A total of 389 of the 479 newly diagnosed myeloma patients with 1q21 FISH results had complete data for multivariate proportional hazards regression analysis in this study.
To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85. To convert albumin level from grams per deciliter to grams per liter, multiply grams per deciliter by 10
HR indicates hazard ratio; other abbreviations are explained in Table 1
del(13) was defined by interphase FISH using a D13S31 probe. If at least 80% of clonal plasma cells had at least 1 signal of the D13S31 probe, the tumor was considered positive for deletion in this analysis. We also provide a multivariate analysis using a 20% cut point in Table S3