Correlation of t(14q32) and Amp1q21 in newly diagnosed MM
. | No. of patients/total no. (%) . | . | . | |
|---|---|---|---|---|
. | No Amp1q21 . | Amp1q21 . | P . | |
| t(14q32) | 45/80 (56) | 35/80 (44) | .155 | |
| No t(14q32) | 33/47 (70) | 14/47 (30) | < .001 | |
| Total | 78/127 (61) | 49/127 (39) | NA | |
. | No. of patients/total no. (%) . | . | . | |
|---|---|---|---|---|
. | No Amp1q21 . | Amp1q21 . | P . | |
| t(14q32) | 45/80 (56) | 35/80 (44) | .155 | |
| No t(14q32) | 33/47 (70) | 14/47 (30) | < .001 | |
| Total | 78/127 (61) | 49/127 (39) | NA | |
A total of 127 patients had both FISH results for 1q21 and IGH translocations in newly diagnosed MM enrolled in Total Therapy 2. The presence of t(14q32) was defined by interphase FISH using the commercial IGH break-a-part probes (Vysis). If at least 20% of clonal plasma cells had split signals of IGH probes, it was considered the presence of t(14q32)
NA indicates not applicable