Vector copies per peripheral-blood lineage cell by quantitative real-time DNA PCR
Months after gene therapy . | P1 . | P2 . | P3 . | ||||||
---|---|---|---|---|---|---|---|---|---|
T cell . | B cell . | Myeloid . | T cell . | B cell . | Myeloid . | T cell . | B cell . | Myeloid . | |
3 | 0.04* | ND | ND | 0.17* | ND | ND | 0.28 | 0.10 | 0 |
6 | 0.005 | 0.001 | 0.001 | 1.37 | 0.44 | 0 | 0.24 | 0.10 | 0.001 |
9 | 0 | 0 | 0.016 | 0.93 | 0.08 | 0.07 | 0.25 | 0.05 | 0.001 |
12 | 0.03 | 0.004 | 0.001 | 1.11 | 0.06 | 0.04 | 0.22 | 0.03 | 0.011 |
18 | 0.05 | 0.06 | 0.004 | 1.04 | 0.04 | 0.04 | NA | NA | NA |
24 | 0.04 | 0.03 | 0 | NA | NA | NA | NA | NA | NA |
27 | 0.06 | 0.003 | 0 | NA | NA | NA | NA | NA | NA |
Months after gene therapy . | P1 . | P2 . | P3 . | ||||||
---|---|---|---|---|---|---|---|---|---|
T cell . | B cell . | Myeloid . | T cell . | B cell . | Myeloid . | T cell . | B cell . | Myeloid . | |
3 | 0.04* | ND | ND | 0.17* | ND | ND | 0.28 | 0.10 | 0 |
6 | 0.005 | 0.001 | 0.001 | 1.37 | 0.44 | 0 | 0.24 | 0.10 | 0.001 |
9 | 0 | 0 | 0.016 | 0.93 | 0.08 | 0.07 | 0.25 | 0.05 | 0.001 |
12 | 0.03 | 0.004 | 0.001 | 1.11 | 0.06 | 0.04 | 0.22 | 0.03 | 0.011 |
18 | 0.05 | 0.06 | 0.004 | 1.04 | 0.04 | 0.04 | NA | NA | NA |
24 | 0.04 | 0.03 | 0 | NA | NA | NA | NA | NA | NA |
27 | 0.06 | 0.003 | 0 | NA | NA | NA | NA | NA | NA |
ND indicates not done; NA, not applicable.
Total buffy coat and not purified CD3+ T cells at indicated dates.