Management of CNS leukemia present at diagnosis
| 1. Intrathecal or intraventricular (Ommaya reservoir) methotrexate 12.5 mg three times weekly until clearance of the cerebrospinal fluid. |
| 2. Lucovorin 10 mg/m2 intravenously or orally every 6 hours for 4 doses, starting 24 hours after the administration of methotrexate. |
| 3. Cranial irradiation 2400 cGy and 1200 cGy to the spinal cord administered concurrently with phase 2 of induction. |
| 4. Systemic chemotherapy is not to be delayed while intrathecal or radiation therapy is given. |
| 1. Intrathecal or intraventricular (Ommaya reservoir) methotrexate 12.5 mg three times weekly until clearance of the cerebrospinal fluid. |
| 2. Lucovorin 10 mg/m2 intravenously or orally every 6 hours for 4 doses, starting 24 hours after the administration of methotrexate. |
| 3. Cranial irradiation 2400 cGy and 1200 cGy to the spinal cord administered concurrently with phase 2 of induction. |
| 4. Systemic chemotherapy is not to be delayed while intrathecal or radiation therapy is given. |